Isotretinoin decreases the size and activity of the sebaceous glands in the skin, which reduces the amount of sebum that is produced.
Isotretinoin is not indicated for the treatment of prepubertal acne and is not recommended in patients less than 12 years of age due to a lack of data on efficacy and safety.
Isotretinoin may rarely cause disease of the pancreas pancreatitis that may rarely be fatal. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Adherence to therapy must also be considered. Your doctor will tell you when and where to have these tests.
Acetazolamide Acetazolamide may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy. The patients 25-hydroxy vitamin D3 25 OH vit D3 levels were measured before treatment and at the sixth month of treatment.
Ask your doctor before use if you are taking the following medications:
Postoperative atrial fibrillation is often well tolerated and usually resolves on its own within 6 to 8 weeks after surgery, but it does increase the risk for various complications, including thromboembolic events and ventricular arrhythmias that can compromise hemodynamic status or cause acute congestive heart failure.
If a decision is made to continue the drug, patients should be advised to not drive and to avoid other potentially dangerous activities.
Serotonin syndrome is a type of serotonin toxicity.
If you stop taking this drug suddenly, it can cause serious problems.
The resultant increase in serum dofetilide concentrations could increase the risk of torsade de pointes.
Isotretinoin must not be used by female patients who are or may become pregnant. See a picture of the Skin and learn more. Isotretinoin and tetracycline in the management of severe nodulocystic acne.