Selegiline HCl is readily absorbed from the gastrointestinal tract.
If you are also taking levodopa, you may experience more side effects from the levodopa when taking selegiline.
It works by increasing the amount of dopamine a natural substance that is needed to control movement in the brain. At least 14 days should lapse between the discontinuation of selegiline and initiation of treatment with any drug known to interact with selegiline. In view of the high degree of binding to plasma proteins by selegiline particular attention must be given to patients who are being treated with medicines with a narrow therapeutic margin index, such as digitalis and or anticoagulants.
If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Therefore, the concomitant use of selegiline and tricyclic antidepressants is contraindicated.
Ask your doctor before use if you are taking the following medications:
Agents that cause clinically significant thrombocytopenia could theoretically result in an increased risk of bleeding due to additive pharmacodynamic effects, and combinations of these agents should be approached with caution.
Metabolism can occur by way of glucuronidation at 17 and 3 positions, methylation, or sulfation at the 3 position.
Recipients of this Drug Alert should bring it to the attention of relevant contacts by copy of this letter.
Acute cardiac toxicity is an increasingly recognised potential adverse effect of antimicrobial drug treatment.
With your fingertips, press the sticky side of the patch firmly against the skin site that was just washed and dried. Fluoxetine should not be used less than 14 days after discontinuation of selegiline. Do not stop taking the medicine without speaking to your doctor first. Everyday Health Drugs Monoamine Oxidase Inhibitors Selegiline. Patient education is very important with this product because of potentially serious food and drug interactions.
Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ.