Studies have related the risk of an increased hypotensive response to concomitant administration of selegiline and levodopa, in patients with cardiovascular risk.
The available safety data concerning the use during pregnancy and lactation is insufficient to justify the use of selegiline in these patient groups.
The PDRG report of excess mortality associated with selegiline caused much controversy.
Target Actions Organism A Amine oxidase flavin-containing B. The combination of selegiline and oral contraceptives or drugs for hormone replacement therapy, should be avoided, as this combination may increase the bioavailability of selegiline.
MAO-B inhibitors are contraindicated with meperidine, methadone, propoxyphene, and dextromethorphan. Subjective Possibly greatest during the first few hours. Rasagiline is an MAO-B inhibitor that is not metabolized to toxic amphetamine metabolites and is several-fold more potent than selegiline. Fluoxetine should not be used less than 14 days after discontinuation of selegiline.
Ask your doctor before use if you are taking the following medications:
INH and SM were contraindicated in one patient due to polyneuropathy and deafness, and one patient reacted with grand mal epilepsy to INH and with hepatic intolerance to RMP and PZA.
Alcohol can make you more drowsy and dizzy.
Do not use this drug more often than prescribed.
In addition to you watching for changes in your mood or behavior, your family or caregivers should be alert to changes in your mood or symptoms.
Do not stop or change your treatment with selegiline without talking to your doctor. Your doctor may occasionally change your dose to make sure you get the best results. These are not all the side effects of selegiline. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior.
Selegiline may facilitate smoking cessation by inhibition of nicotine metabolism or by mimicking the effects of cigarette smoke on MAO. The concomitant intake of alcohol should be avoided.
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