Use of Diclofenac Potassium tablets in patients with hepatic porphyria may trigger an attack.
In addition, precorneal retention of diclofenac sodium has been reported to be increased by the use of liposomes.
Older adults may be at higher risk for this effect. Affected organisms Humans and other mammals Pathways Pathway Category Diclofenac Action Pathway Drug action Pharmacogenomic Effects ADRs Browse all title About SNP Mediated Effects ADRs.
It s important to take your diclofenac tablets or capsules after a meal or snack, or with a drink of milk. They work as well as each other. Exercises for OA of the Knee Slideshow. But if you use too much and get any side effects, tell your doctor straight away. Do not cover the treated area with clothes or gloves for 10 minutes after you apply the gel Voltaren , or until the liquid Pennsaid has dried if you are using the liquid. Enter a drug name and diclofenac.
This medication may raise your blood pressure.
Ask your doctor before use if you are taking the following medications:
As the severity of liver disease increases, the extent of extraction decreases.
Hyperpyretic crises, severe convulsions, and fatalities have occurred when similar tricyclic antidepressants were used in such combinations.
That means that studies have shown that diclofenac can be a risk to the offspring of lab animals. The use of multiple NSAIDs is not generally recommended because of the potential for increased side effects, such as gastrointestinal upset and bleeding. See Table 2 for clinically significant drug interactions with diclofenac.
New insights into the structural features and functional relevance of human cytochrome P450 2C9. Only one in five patients, who develop a serious upper GI adverse event on NSAID therapy, is symptomatic.