Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis.
Your doctor has weighed the risks of you taking Azathioprine AN against the benefits the medicine is expected to have for you.
The efficacy of azathioprine in reducing the daily dose of corticosteroid was demonstrated in a randomized trial, but only after 18 months of treatment.
Careful dosage instructions should be given to the patient, especially when IMURAN is being administered in the presence of impaired renal function or concomitantly with allopurinol see DRUG INTERACTIONS subsection and DOSAGE AND ADMINISTRATION.
Things to know before you start. Accurate phenotyping red blood cell TPMT activity results are not possible in patients who have received recent blood transfusions. Genetic polymorphisms of TPMT can lead to excessive drug toxicity, thus assay of serum TPMT may be useful to prevent this complication. Patients on IMURAN should have complete blood counts, including platelet counts, weekly during the first month, twice monthly for the second and third months of treatment, then monthly or more frequently if dosage alterations or other therapy changes are necessary.
Death associated with pancytopenia has been reported in patients with absent TPMT activity receiving azathioprine.
Ask your doctor before use if you are taking the following medications:
This drug may cause a serious skin reaction.
Treatment should be initiated at a dose of 30 mg and titrated to a maximum dose of 60 mg based upon response and tolerability.
Where possible, these drugs should not be taken during pregnancy, except where the benefits outweigh the risks. Azathioprine will be prescribed for you by a specialist doctor who is experienced in treating your condition. Your condition can cause complications in a medical emergency. It is also used by people with rheumatoid arthritis as well as other inflammatory conditions or following an organ transplant.
Contact the applicable plan provider for the most current information.