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Common information

clozapine hydrochloride 25 mg

Let your family and friends know you are taking clozapine so they can support you and help you look out for side effects.

Patients newly started on clozapine must have an FBC taken weekly for the first 18 weeks of treatment then fortnightly for the next 34 weeks.

Small Effects of Valproic Acid on the Plasma Concentrations of Clozapine and its Major Metabolites in Patients With Schizophrenic or Affective Disorders.

Coroners warn health secretary of clozapine deaths. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Only available through a restricted access program because of risk for neutropenia i.

Screen for myocarditis if in first 4 weeks of therapy Consult with psychiatrist before cessation. Clozapine is a lifesaving drug, but without extra care, it can also shorten the life span of patients. Inform your doctor if your condition persists or worsens. Older adults may be more sensitive to the side effects of this drug, especially constipation, trouble urinating, drowsiness, dizziness, lightheadedness, and QT prolongation see above.

If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking clozapine or similar medications may increase this risk.

Side Effects

  • If treatment interrupted
  • Dry mouth,
  • Drowsiness,
  • Upset stomach

Used for

  • Schizophrenia
  • Borderline Personality Disorder
  • Paranoid Disorder

Before using

Ask your doctor before use if you are taking the following medications:

Pregnancy

  • If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, apprise the patient of the potential hazard to a fetus.
  • Any woman taking this medication who may become pregnant should practice effective birth control and contact her doctor immediately if pregnancy is suspected while taking this medication.
  • Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Common dosage / Overdose

  • Dosage adjustment of methadone may be necessary.
  • Stomach upset is a common side effect with both medications, using the lowest possible dosage can minimize this side effect.
  • As in any case of overdose, general supportive measures should be utilised.
  • Apply this medication to the affected skin, usually once or twice a day or as directed by your doctor.

Warnings

This drug may cause serious harm to your unborn baby.

Do not use this medicine to treat acne, rosacea, or a rash around the mouth.

Without adequate amounts of antioxidants, these free radicals can damage cells which can lead to the development of heart disease.

These side effects are more likely to occur, at the start of the treatment and after dose increases.

Reduction of cholesterol levels in the blood has been shown to reduce the risks associated with heart disease, such as heart attack.

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You should tell your doctor if you use tobacco products before taking this medicine. Do not save them for your next dose. Not all possible interactions are listed here.

Resources

  • http://www.rxlist.com/clozaril-drug.htm

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