Clomipramine may intensify the effects of other drugs that act on serotonin levels, possibly producing serotonin syndrome, a rare but dangerous condition with fever, sweating, tremors, and changes in mental state.
If severe neurological or psychiatric reactions occur, clomipramine should be withdrawn.
In the event of severe acute reactions such as DRESS, discontinue clomipramine therapy immediately and institute appropriate treatment.
Suicide suicidal thoughts or clinical worsening. Patients requiring co-medication for hypertension should therefore be given antihypertensives of a different type e. Anafranil clomipramine hydrochloride Capsules USP 25 mg, 50 mg, and 75 mg.
Each contraindication describes a scenario in which the drug is not to be used. This drug is used for major depression, obsessive-compulsive disorders and phobias, muscle weakness in those with a sleep disorder called narcolepsy.
Caution is called for when giving tricyclic antidepressants to patients with severe hepatic disease and tumours of the adrenal medulla e.
Ask your doctor before use if you are taking the following medications:
Due to the inhibition of renal prostaglandins by salicylates, concurrent use of salicylates and other nephrotoxic agents, such as vancomycin, may lead to additive nephrotoxicity.
If digitalis toxicity is suspected, elective cardioversion should be delayed.
Do not use it in larger amounts or for longer than recommended.
Hyperpyrexia should be controlled by whatever external means are available, including ice packs and cooling sponge baths, if necessary. The pupillary dilation that occurs following use of many antidepressant drugs including Anafranil may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. This drug may increase your risk of seizures.
You may need to show airport staff the pharmacy label for your medication. BDD may remit along with major depression, but treatment often fails or is only partially effective. Our content does not constitute a medical consultation.