P450 enzymes, particularly CYP3A4, CYP2C19 may accelerate the metabolism and decrease the efficacy of clomipramine.
The mothers took between 75mg and 125mg of clomipramine daily.
An overdose of clomipramine can be fatal.
Tricyclic antidepressants may potentiate the effects of these drugs e. Generic Name Clomipramine hydrochloride Product Name Clomipramine Terry White Chemists.
Your dose may need to be gradually decreased. Do this even if there are no signs of discomfort or poisoning. Pregnancy and Breast Feeding It s important for you and your baby that you stay well during your pregnancy. Use this medication regularly in order to get the most benefit from it.
Clomipramine may potentiate the cardiovascular effects of adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine e.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including fever, swollen lymph nodes, rash, itching swelling especially of the face tongue throat , severe dizziness, trouble breathing.
Ask your doctor before use if you are taking the following medications:
If you drink alcohol while you are taking this medicine, your blood pressure may drop, making you feel dizzy or faint.
Your doctor may ask you to stop smoking or at least cut down.
Monitor patients for signs and symptoms of hematologic toxicity and monitor liver function, another indicator of thioguanine toxiciy.
After the dose has been increased, the total daily dose may be given once daily, at bedtime. You should have regular dental checkups and practice good dental hygiene while taking this medication.
Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Control of cataplexy should be achieved within 24 hours of reaching the optimal dose.