Esomeprazole is metabolised by CYP2C19 and CYP3A4.
Concomitant administration of esomeprazole has been reported to increase the serum levels of tacrolimus.
It is usually taken once a day, at the same time every day, around 1 hour before eating. However, caution should be exercised when esomeprazole is given at high doses in elderly patients. Depending on the reason you take esomeprazole, you may take a higher dose to begin with, usually for a month or two. Some of this increase may be due to other risk factors.
Esomeprazole doses should be slowly lowered, or tapered, before discontinuing to prevent this rebound effect.
Ask your doctor before use if you are taking the following medications:
Taking certain products together can cause you to get too much of this type of medication.
Be aware of the alcohol content of other common products such as cough and cold medicines, mouth washes, tonics, sauces, vinegars, and other food products.
Do not use a kitchen teaspoon as it will not give the right amount of medicine.
An alternative method or an additional method of contraception should be utilized during modafinil therapy and continued for one month after modafinil discontinuation.
The risk of hypokalemia secondary to diuresis and natriuresis is increased when larger doses are used, when the diuresis is brisk, when severe cirrhosis is present and during concomitant use of corticosteroids or ACTH.
Follow all directions given to you by your doctor or pharmacist carefully. The dose of cilostazol should be reduced from 100 mg twice daily to 50 mg twice daily when given with esomeprazole.
While an initial starting dose of 40 medical once daily is typical, downward titration to the lowest effective dose should be the goal once symptoms are in good control.