This drug may make repaglinide less effective.
Repaglinide should be taken by mouth before every meal, up to a half hour before meals.
Pharmacokinetic Parameters for Repaglinide in Healthy Subjects.
Such drugs include thiazide diuretics for example, hydrochlorothiazide Microzide , loop diuretics for example, furosemide Lasix , amphetamines, glucocorticoids such as prednisone and methylprednisolone Medrol , estrogens, isoniazid, phenothiazines such as chlorpromazine Thorazine , phenytoin Dilantin , somatropin Genotropin , decongestants and thyroid drugs.
High concentrations of ATP inhibit ATP-sensitive potassium channels causing membrane depolarization. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones.
May be dosed 2, 3, or 4 times a day in response to changes in meal pattern. Examples include clopidogrel, gemfibrozil, trimethoprim, azole antifungals such as itraconazole , macrolide antibiotics such as erythromycin , rifamycins such as rifabutin , St. Repaglinide increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner. Repaglinide was usually given three times a day in doses depending on clinical need. It is important to eat a healthful diet.
Plasma half-lives, duration of action and metabolism of the sulphonylureas.
Ask your doctor before use if you are taking the following medications:
In some cases, this may be harmful and your doctor may advise you to avoid certain food.
The combination of alcohol and NSAIDs is very dangerous, as it can lead to serious liver damage.
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Also tell them about any supplements you take. Call your doctor right away if you have any of these signs. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.