Pioglitazone should be discontinued if any deterioration in cardiac status occurs.
It is not known if pioglitazone passes into breast milk.
Mean levels of liver enzymes decreased with treatment with pioglitazone.
Pioglitazone can cause fluid retention, which may exacerbate or precipitate heart failure. The recommended starting dose for patients with congestive heart failure NYHA Class I or II is 15 mg once daily.
Terms that are reported represent those that occurred at an incidence of 5 and more commonly in patients treated with ACTOS than in patients who received placebo. The PROspective pioglitAzone Clinical Trial In macroVascular Events PROactive study was the first randomized, double-blind outcome study in patients with type 2 diabetes managed with diet and or oral blood glucose-lowering drugs and or insulin who had a history of macrovascular disease, assessing the effect of pioglitazone on the secondary prevention of macrovascular events.
Type 2 Diabetes Learn the Warning Signs. Type 2 Diabetes Learn the Warning Signs. In vivo angiogenesis was increased two-fold.
Ask your doctor before use if you are taking the following medications:
Taking this drug for 3 months or longer can cause low magnesium levels in your body.
Over time, the drug can lead to a decrease in bone mineral density.
However, due to its toxicity and overlapping therapeutic and toxic concentrations, flecainide is mostly reserved for use in patients who failed to respond to other sodium channel blockers.
In the event of acute overdosage, reversible renal toxicity has been reported in some cases.
Tryptophan, a common dietary supplement, can cause headaches, nausea, sweating, and dizziness when taken with any SSRI.
Keep all medicines out of the reach and sight of children. In these trials, over 6000 patients have been treated with ACTOS for six months or longer, over 4500 patients have been treated with ACTOS for one year or longer, and over 3000 patients have been treated with ACTOS for at least two years. You will be watched closely for signs of heart failure when you start pioglitazone and if your dose is raised.
If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Tan MH, Baksi A, Krahulec B, et al.