Individual case reports suggest a possible interaction between warfarin and cranberry juice, in most cases leading to an increase in INR or bleeding event.
There have also been reports from the UK about a possible interaction between warfarin and cranberry, so patients taking warfarin were advised to limit or avoid drinking cranberry juice.
Therefore dosing adjustments, close monitoring, and use of alternative agents should be considered when combining warfarin with certain medications. Warfarin is an oral anticoagulant, a drug that inhibits the clotting of blood.
Do not stop taking warfarin without talking to your doctor. The INR ensures that PT results obtained by different laboratories can be compared. This medication can cause heavy bleeding. Warfarin is a type of medicine known as an anticoagulant, or blood thinner. S-warfarin has higher potency than R-warfarin and genetic polymorphisms in CYP2C9 may dramatically decrease clearance of and increase toxicity of the medication.
Patients typically require 2 to 10 mg of warfarin daily.
Ask your doctor before use if you are taking the following medications:
Advise patient to report to physician if any nodule enlarges or becomes tender or hard during therapy.
Dose reductions or discontinuation of valproate should be considered in patients with decreased food or fluid intake and in patients with excessive somnolence.
Some foods can make warfarin less effective. It works by decreasing the clotting ability of the blood. CYP2C9 and VKORC1 genes may modify response. Author Mr Michael Stewart Peer reviewer Sid Dajani. May potentiate warfarin response because of decreased metabolism and impaired synthesis of clotting factors. Acute ingestion of a large amount of alcohol may inhibit the metabolism of warfarin and increase INR.