In patients who are poor CYP2C19 metabolisers, clopidogrel at recommended doses forms less of the active metabolite of clopidogrel and has a smaller effect on platelet function.
Pharmacists should check whether patients buying omeprazole are also taking clopidogrel.
It is not known whether clopidogrel passes into breast milk or if it could harm a nursing baby.
It should be noted this decision should not occur in isolation, especially in patients who are high-risk e. Considering that death from intracranial or extracranial bleeding, or from ischaemic stroke, are equally important, and that non-fatal haemorrhagic and ischaemic stroke have a similar distribution of functional outcomes, we considered our key outcomes all cause mortality, non-fatal stroke, and non-fatal serious bleeding.
Rarely, clopidogrel has been associated with thrombotic thrombocytopenia TTP. Patients with any loss of function allele will not effective metabolize clopidogrel which leads to the inability to inhibit platelet activity. It is not known if clopidogrel is secreted into the breast milk. Bioavailability has not been found to be affected by food.
Ask your doctor before use if you are taking the following medications:
According to the manufacturer of asenapine, the drug should be avoided in combination with other agents also known to have this effect.
Toxicity in animals was found at doses equivalent to human therapeutic doses.
Patients should be regularly monitored for the development of impulse control disorders.
Tell your doctor if you take aspirin, especially if you have had a stroke. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. Clopidogrel will help prevent serious problems with your heart and blood vessels only as long as you take the medication.
Platelet inhibition by clopidogrel bisulfate is irreversible and will last for the life of the platelet. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of clopidogrel.