Concerned for the well being of a friend who was prescribed ondansetron for nausea and vomiting associated with pregnancy, Susan would like to know if it is safe for her friend to be taking it.
However, as animal studies are not always predictive of human response the use of ondansetron in pregnancy is not recommended.
Ondansetron is used to prevent and treat feelings of sickness and vomiting caused by chemotherapy, radiotherapy and after surgery.
This resulted in a significant increase in the clearance of ondansetron. In addition, no cases of isolated cleft palate were identified in the aforementioned 2 large retrospective cohort studies. All intravenous doses should be diluted in 50-100 ml of saline or other compatible infusion fluid see section 6.
Most reports have been associated with concomitant use of serotonergic drugs e. This may reflect some reduction of first-pass metabolism at higher oral doses. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron. If these effects persist or worsen, notify your doctor promptly. In a pharmacokinetic trial of 16 epileptic patients maintained chronically on CYP3A4 inducers, carbamazepine, or phenytoin, a reduction in AUC, Cmax, and t of ondansetron was observed.
Repeat dosing in all adults including elderly patients.
Ask your doctor before use if you are taking the following medications:
Besides avoiding alcohol, patients should also avoid any products containing alcohol.
Unlike some TCAs, not associated with severe cardiotoxicity, has mild sedative action, and causes slight orthostatic hypotension.
Angiotensin II increases blood pressure by increasing total peripheral resistance, increasing sodium and water reabsorption in the kidneys via aldosterone secretion, and altering cardiovascular structure.
There appears to be an increased risk of agranulocytosis and leukopenia in the geriatric population.
Full blood counts should be closely monitored before, during and after treatment.
It is a group of 100 different diseases, and. No detrimental effects on such activities are predicted from the pharmacology of ondansetron. Thus, the effect of ondansetron in the management of the nausea and contain induced by cytotoxic chemotherapy and radiotherapy is probably due to antagonism of 5HT3 receptors on neurons located both in the peripheral and central nervous system.
PKU is an inherited condition in which a special diet must be followed to prevent mental retardation. Subscribe to receive email notifications whenever new articles are published.