Methotrexate treats cancer by slowing the growth of cancer cells.
Make sure that you discard any methotrexate that is outdated.
Methotrexate is a type of drug called an antimetabolite or antifolate.
Previously it was recommended that men stop methotrexate three months before trying for a baby, but research has now been done that suggests that they may not need to. Your doctor will monitor you more carefully and may need to give you a lower dose of methotrexate or stop your treatment with methotrexate. Low-dose methotrexate has been associated with development of malignant lymphomas.
Methotrexate is effective and safe if used correctly. Call your doctor immediately if you experience any of the following symptoms dry cough, fever, or shortness of breath. Try to keep your house clean and hygienic, especially the kitchen, bathrooms and toilets. In a pioneer study in juvenile idiopathic poly arthritis JIA the efficacy of combining MTX with the 75 kD tumour necrosis factor TNF receptor fusion protein etanercept ETN was higher than MTX placebo in patients who had been resistant to MTX Lovell et al.
Rather than just masking pain, methotrexate reduces it by reducing severity of the disease. Rescuing patients for whom oral MTX monotherapy fails.
Ask your doctor before use if you are taking the following medications:
In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis, and hepatic failure, some of them with fatal outcomes, have been reported.
This medical condition can cause lower than normal heart rate.
The least dangerous cases can lead to hives or an itchy rash.
Patients should be advised to stop the drug immediately if they develop any type of rash and contact their physicians as soon as possible Patients should promptly report signs or symptoms of unexplained weight gain or edema to their physicians.
Your doctor may monitor you for worsening or new suicidal thoughts and behaviors.
IMPORTANT WARNING section or a low level of folate in your blood. Pretreatment liver biopsy should be performed for patients with a history of excessive alcohol consumption, persistently abnormal baseline liver function test values or chronic hepatitis B or C infection.
RA who are taking methotrexate experience serious liver damage.