Pulmonary toxicity in a patient with psoriasis receiving methotrexate therapy.
Methotrexate causes embryotoxicity, abortion, and fetal defects in humans.
Tell your doctor right away if you have any serious side effects, including mouth sores, diarrhea, signs of anemia such as unusual tiredness, pale skin , signs of liver problems such as dark urine, persistent nausea vomiting, stomach abdominal pain, yellowing eyes skin , easy bruising bleeding, black stools, enlarged glands lymph nodes, bone pain, unusual pain and discoloration of the skin, signs of kidney problems such as change in the amount of urine , dry cough, muscle weakness.
Report a dry cough, shortness of breath, or any other respiratory problem to your doctor. If you take methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body.
Indicated for management of severe, active rheumatoid arthritis RA in adults who have had an insufficient response or intolerance to an adequate trial of first-line therapy including full dose NSAIDs Initial 7. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate.
Your doctor will tell you how often you should take methotrexate. Call your doctor for medical advice about side effects. Subacute toxicity with intrathecal administration paralysis of extremities, cranial nerve palsy, seizure or coma.
For use in life threatening neoplastic disease or patients with psoriasis or rheumatoid arthritis with severe recalcitrant disabling disease, not adequately responsive to other forms of therapy.
Ask your doctor before use if you are taking the following medications:
Patients receiving sulfonylureas should be closely monitored for loss of diabetic control when therapy with sympathomimetic agents is instituted.
Use this drug with caution if you have poor liver function or progressive liver disease.
Special caution is indicated in the presence of preexisting liver damage or impaired hepatic function. Yet the study indicates that most of these problems were relatively minor. Patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency syndromes should not receive methotrexate. Monitoring signs of myelosuppression can reduce complications such as severe anemia, potential bleeding and sepsis.