The manufacturer also notes a report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro.
Nifedipine is a substrate of the CYP3A4 isoenzyme and its use is contraindicated with potent inducers of CYP3A4, such as phenytoin.
Rates of treatment-related AE were similar 33. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
They may view the relief of symptoms as more important than the emerging data that suggest a link between the use of nifedipine, as well as possibly other short-acting dihydropyridines, and an excess of cardiovascular events.
Talk to your doctor if you are using marijuana cannabis. These usually improve after a few days of treatment. Many studies have demonstrated the tocolytic effect of nifedipine.
A second proposed mechanism for the drug s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. The usual maximum doses of nifedipine are. From the Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, NC C.
Ask your doctor before use if you are taking the following medications:
Dosage to reduce the risk of heart attack, stroke, or death.
Talk to your doctor about your risk of these serious side effects.
Women of childbearing age should discuss the risks and benefits of this medication, other treatment options, and use of reliable forms of birth control with their doctor.
Do not break, crush or chew them, or open up the capsules unless your doctor or pharmacist has said you can. Coadministration has been associated with an increased risk of hypotension and shock. Keep all medicines out of the reach and sight of children. Electrolyte abnormalities consisted of a mild, transient elevation of serum creatinine, and modest elevations of LDH and CPK, but normal SGOT.
Monitor blood pressure closely during concurrent use of these medications. Avoid eating grapefruit or drinking grapefruit juice while taking this medication unless your doctor instructs you otherwise.