Metoprolol also reduces the force of contraction of heart muscle and thereby lowers blood pressure.
Quinidine is also a known inhibitor of CYP2D6 and metoprolol is a CYP2D6 substrate.
The most common side effects with metoprolol ER are tiredness, dizziness, depression, shortness of breath, slow heart rate, low blood pressure, diarrhea, itching, and rash.
The onset of action for oral immediate-release tablets is within 1 hour with a duration of effect variable depending on the dose given. Some selective serotonin reuptake inhibitor SSRI antidepressant drugs may also affect how metoprolol works. Swallow the whole or split tablet without crushing or chewing. Beta blockers reduce placental perfusion and may cause foetal death and premature birth.
IV Adults MI 5 mg q 2 min for 3 doses, followed by oral dosing. Patients who have ingested cocaine or methamphetamine have traditionally had a contraindication to the use of selective beta-blocker such as metoprolol. It is recommended that metoprolol should not be administered during pregnancy or lactation unless it is considered that the benefit outweighs the possible risk to the foetus infant.
Ask your doctor before use if you are taking the following medications:
This is because good control of blood sugar levels reduces the risk of complications later on.
Pamelor may cause symptoms of the manic phase to emerge.
Your doctor should carefully discuss the risks and benefits of the medicine with you and your child before treatment is started.
If you get warning symptoms that you might faint, such as feeling dizzy, lightheaded, sick or sweaty, you should lie down or sit down with your head between your legs until the symptoms pass.
Metoprolol should be used with caution in severe hepatic disease, since drug clearance may be reduced. In patients deficient in CYP2D6, the combination has little effect on their usual metabolism of metoprolol. Initial treatment consisted of intravenous followed by oral administration of Lopressor or placebo, given in a coronary care or comparable unit.
European investigators sought to compare the effects of carvedilol and metoprolol on clinical outcomes in HF.