There is no evidence that airway smooth muscle or inflammatory cells concentrate theophylline to achieve higher intracellular than circulating concentrations.
This information should not be used to decide whether or not to take theophylline injection or any other medicine.
It has been suggested that theophylline may exert its effects in asthma via some action outside the airways.
Guidelines for COPD treatment classify theophylline as a third-line bronchodilator, after inhaled anticholinergics ipratropium and glycopyrrolate and beta2-agonists albuterol, arformoterol, formoterol, indacaterol, levalbuterol, salmeterol, vilanterol , or a combination of both. Theophylline s beneficial effects for COPD patients have a narrow therapeutic index small differences in dose or blood concentration may lead to serious therapeutic failures or adverse drug reactions.
Peak serum concentration 30 mcg mL. For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis.
Affected organisms Humans and other mammals Pathways Pathway Category Caffeine Metabolism Metabolic Pharmacogenomic Effects ADRs Browse all title About SNP Mediated Effects ADRs. Theophylline was primarily used as a bronchodilator, and it relaxes large and small human airways in vitro , acting as a functional antagonist by increasing intracellular cAMP concentrations. The improvement in lung function is relatively slow, suggesting an antiinflammatory rather than a bronchodilator effect of theophylline.
Humans A cGMP-specific 3 ,5 -cyclic phosphodiesterase.
Ask your doctor before use if you are taking the following medications:
Complications of chronic overdosage include peripheral neuropathy and hepatic toxicity.
Overdose can cause massive diuresis resulting in dehydration, volume depletion and electrolyte disturbances with consequent hypotension and cardiac toxicity.
The mechanism for this increased risk is not known.
People with severe heart disease seem to be more at risk.
But over more than three decades, the company repeatedly fought against safety warnings, dosage restrictions and other measures meant to safeguard users of the drug, according to company memos, court records, documents obtained under the Freedom of Information Act, and interviews with hundreds of regulatory, corporate and medical officials.
Continue to take theophylline unless your doctor tells you otherwise. Lee et al demonstrated that stopping smoking for 1 week resulted in a 37. Particularly in the setting of theophylline overdose induced convulsions, efficacy of some anticonvulsant drugs, such as benzodiazepines, may be reduced through suspected pharmacodynamic interactions.
Buy augmentin 875 mg tablets https://augmentin875mg.net online in US. Both active ingredients of Augmentin, amoxicillin and clavulanic acid, are rapidly and completely absorbed from the gastrointestinal tract after oral administration. The absorption of active ingredients is optimal if Augmentin is taken at the beginning of a meal.