The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants.
Appreciable formation of glucuronide conjugates of each metabolite and of indomethacin are formed.
Increased constriction of the ductus arteriosus with combined administration of indomethacin and betamethasone in fetal rats.
Label At birth, the ductus arteriosus is normally closed as the tension of the oxygen increases significantly after birth. In patients who have persistent night pain and or morning stiffness, the giving of a large portion, up to a maximum of 100 mg 20 mL , of the total daily dose at bedtime may be helpful in affording relief.
Indomethacin suppositories usually are used two to four times daily. The incidence for group 2 was based on reports in clinical trials, in the literature, and on voluntary reports since marketing. NSAIDs cause an increased risk of serious gastrointestinal GI adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
This drug may rarely cause serious possibly fatal liver disease. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA Cedars-Sinai Medical Center in Los Angeles.
View Related Products by Product Action. Indomethacin may cause other side effects.
Ask your doctor before use if you are taking the following medications:
Patients should be informed of the possibility of adverse reactions and of the need for careful medical supervision.
Stopping the medicine too early may cause the infection to be more difficult to treat.
Talk to your pharmacist for more details. DHHS Program Support Center Supply Service Center Direct Dispensing Inc.