There was no significant difference between etoricoxib and diclofenac in the rate of cardiovascular thrombotic events.
Etoricoxib 60 mg once daily showed maximal efficacy in treating OA in this study.
Etoricoxib at 60 and 90 mg had no effect on methotrexate plasma concentrations or renal clearance.
The subset of overall upper GI events considered complicated included perforations, obstructions, and complicated bleeding the subset of upper GI events considered uncomplicated included uncomplicated bleeds and uncomplicated ulcers.
Pharmacotherapeutic group Antiinflammatory and antirheumatic products, nonsteroids, coxibs , ATC code MO1 AH05. Comprehensive structured data on known drug adverse effects with statistical prevalence. N total number of patients included in Per-protocol population. The decision to prescribe a selective COX-2 inhibitor should be based on an assessment of the individual patient s overall risks see sections 4. In some patients with insufficient relief from symptoms, an increased dose of 90 mg once daily may increase efficacy.
Ask your doctor before use if you are taking the following medications:
Caution is advised when medicinal products metabolised by this enzyme are administered concomitantly.
Use in nursing mothers is not recommended unless, in the judgment of the physician, the benefit outweighs the risk.
To view content sources and attributions, please refer to our editorial policy. This could increase the risk of heart attack or stroke even further. Osteoarthritis is caused by inflammation, breakdown, and eventual loss of cartilage in the joints.