Cilostazol inhibits platelet aggregation in a reversible manner.
Cilostazol reduces the rate of decline in renal function in Chinese patients with type 2 diabetes and mild to moderate renal impairment secondary to diabetic nephropathy.
The request followed reports to the Spanish agency of serious adverse effects affecting the heart including fatal heart attacks, angina and arrhythmias irregular heartbeat as well as cases of serious bleeding including bleeding in the brain.
The oral LD 50 of cilostazol is greater than 5 g per kg in mice and rats and greater than 2 g per kg in dogs. Coadministration of omeprazole did not significantly affect the metabolism of cilostazol, but the systemic exposure to 3,4-dehydro-cilostazol was increased by 69 , probably the result of omeprazole s potent inhibition of CYP2C19 see DOSAGE AND ADMINISTRATION.
What are the ingredients in PLETAL. The recommended dosage of cilostazol is 100 mg twice a day. The use of cilostazol in pregnancy has not been adequately studied. The effects of cilostazol include antiplatelet activity and vasodilation. What is cilostazol, and how does it work mechanism of action.
Administration of a single dose of 100 mg cilostazol with 240 ml grapefruit juice an inhibitor of intestinal CYP3A4 did not have a notable effect on the pharmacokinetics of cilostazol.
Ask your doctor before use if you are taking the following medications:
Stopping it suddenly can cause your seizures to return and your doctor will want you to reduce your dose gradually if this is necessary.
Treatment should be initiated at a dose of 30 mg and titrated to a maximum dose of 60 mg based upon response and tolerability.
These may include regular exercise, stopping smoking, and drinking less alcohol.
Do not take a double dose to make up for a missed one. The recommended dosage of cilostazol is 100 mg twice a day. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III.
Cilostazol reduces the pain of intermittent claudication by dilating the arteries, thereby improving the flow of blood and oxygen to the legs. In addition, limited comparative data have shown that cilostazol has superior efficacy compared with pentoxifylline.