Ribavirin also modulates the immune response to hepatitis C virus.
Aerosolized ribavirin has shown minimal efficacy in treating influenza in hospitalized children.
Ribavirin is an inhaled broad-spectrum antiviral agent that is sometimes, albeit controversially, used in the treatment of severely ill or high-risk infants with bronchiolitis. Kinetic analysis of the phosphorylation events have established that the generation of the monophosphate species of ribavirin is the rate-limiting step during conversions of ribavirin to the triphosphate form 21.
Drug interactions occur when one medication affects how another is absorbed, used or flushed out of the body. HIV-positive people should not use RBV with Retrovir, Videx, or Zerit. Regular blood tests are important to monitor this problem. In addition, there was minimal anaemia in this patient cohort. This mechanism of action would also limit development of resistant viral strains.
A second mechanism of action is inferred from data that demonstrated ribavirin triphosphate can be incorporated in the HCV viral genome. Initial attempts at utilizing taribavirin viramidine Figure 1 , a liver-targeted ribavirin analogue that elicits fewer side effects, ultimately failed to demonstrate non-inferiority in Phase III clinical trials 113.
Ask your doctor before use if you are taking the following medications:
Removal of plaques may cause mild bleeding which helps confirm diagnosis of thrush.
Hepatic function should be monitored when treatment is prolonged.
Efficacy depends on the site of infection, method of treatment, age of the animal, and infecting dose of virus. Erythrocytes are a primary target of toxicity for ribavirin in animal studies, including studies in dogs and monkeys.
Patients should use two reliable methods of birth control while taking Ribavirin therapy and for 6 months post therapy. Ribavirin can temporarily weaken the bone marrow. Patients should use two reliable methods of birth control while taking Ribavirin therapy and for 6 months post therapy.
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