Amantadine hydrochloride, USP is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.
Doctors have been using Amantadine for some years to treat brain injuries, but there has never been a comprehensive study to analyze the results.
Convulsions may be induced, and amantadine should be avoided in epileptic patients.
Reduce dose in proportion to reduction in CrCl. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms. Deaths have been reported from overdose with amantadine. Pulmonary edema and respiratory distress including ARDS have been reported.
Humans U Neuronal acetylcholine receptor subunit alpha-4. A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Ask your doctor before use if you are taking the following medications:
This risk is higher after the first dose, after your doctor increases your dose, or if you restart treatment after you stop taking it.
Patients should be advised to avoid intercourse when symptoms are present even if treatment with an antiviral has been initiated.
Physicians and pregnant women should carefully consider the benefits and the risks of all treatment options.
QTc interval must be based on a careful assessment of the potential risks and benefits of doing so for each patient.
Tell your doctor if you are pregnant or plan on getting pregnant. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
When inactivated influenza A virus vaccine is unavailable or contraindicated, Amantadine hydrochloride capsules should be administered for the duration of known influenza A in the community because of repeated and unknown exposure.