Many other medications may also interact with fluconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
Children with porphyria should not take fluconazole.
Fluconazole may cause some unpredictable side effects, including baldness and dizziness.
Clinically or potentially significant drug interactions between DIFLUCAN and the following agents classes have been observed and are described in greater detail below.
In a noncomparative study of children with serious systemic fungal infections, most of which were candidemia, the effectiveness of DIFLUCAN was similar to that reported for the treatment of candidemia in adults.
Fluconazole may affect the way other medicines or products work, and other medicines or products may affect how fluconazole works. During concomitant treatment with fluconazole 200 mg daily and celecoxib 200 mg , the celecoxib Cmax and AUC increased by 68 and 134 , respectively. Systemic exposure to tofacitinib is increased when tofacitinib is coadministered with fluconazole. Frequent monitoring for adverse events and toxicity related to NSAIDs is recommended. Combination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinine.
Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazole.
Ask your doctor before use if you are taking the following medications:
Complications of chronic overdosage include peripheral neuropathy and hepatic toxicity.
Drinking grapefruit juice while taking this drug can cause higher levels of the drug in your body.
Most of these reports involved seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities, and concomitant medications that may have been contributory.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. There was no significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of 50 mg of DIFLUCAN. Fluconazole was active in a variety of animal fungal infection models. Give the missed dose as soon as you remember.