Phenytoin is rapidly absorbed in the small intestine.
Phenytoin appears more effective in the treatment of other epidermolysis bullosa variants.
Because of potential changes in protein binding during pregnancy, the monitoring of phenytoin serum levels should be based on the unbound fraction.
Local Toxicity Including Purple Glove Syndrome. Thus, blood sugar should be monitored closely when phenytoin is administered to patients with diabetes. DRESS typically, although not exclusively, presents with fever, rash, lymphadenopathy, and or facial swelling, in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection.
If the presence of a skin and a mucosal rash is seen, immediate discontinuation of phenytoin is mandatory. Genetic testing may be advised before switching to another aromatic anticonvulsant. It s usual to take phenytoin once or twice a day.
Ask your doctor before use if you are taking the following medications:
In our subgroup analysis by predicted risk score, the rates of cardiac death increased considerably with increasing risk score.
The pharmacodynamic activity and risk of hemorrhage with antithrombotic agents are increased if coadministered with defibrotide.
Solutions in which a haziness or precipitate develops should not be used. Some of the eruptions that phenytoin causes occur only in combination with other medications or treatments. Do not use a kitchen teaspoon as it will not give the right amount. Continuous monitoring of the electrocardiogram and blood pressure is essential and the patient should be observed for signs of respiratory depression.