Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma.
Medicines like imipramine can help to ease the symptoms caused by depression, such as sleep disturbance and a loss of appetite.
Imipramine, the prototypical tricyclic ant 5. Rarely agranulocytosis, thrombocytopenia, eosinophilia, leukopenia, and purpura have occured. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by neurons. Bioavailability ranges from 29-77 due to high inter-individual variability.
Caution should be exercised when imipramine hydrochloride is used with agents that lower blood pressure.
Ask your doctor before use if you are taking the following medications:
Clinical worsening and suicide ideation may occur despite medication.
Hyperkalemia may cause fatal cardiac irregularities, paresthesia, muscle weakness, fatigue, flaccid paralysis of the extremities, bradycardia, and shock.
Drinking heavily while taking this drug increases your risk of severe liver injury.
The combined therapy reduced the stroke risk 23.
Their ability to metabolise and eliminate drugs may be reduced, leading to a risk of elevated plasma concentrations at therapeutic doses. Whether any of the symptoms described above represent such a conversion is unknown. Imipramine belongs to a class of drugs called tricyclic antidepressants. This medication is used to treat depression. Your doctor may adjust your dose of imipramine if you are a poor metabolizer.