Blockade of the H1 receptor by doxepin likely plays a role in reducing wakefulness.
The capsules contain Doxepin Hydrochloride BP equivalent to 25mg doxepin.
Rarely reported are hallucinations, ataxia generally where mixtures of CNS drugs have been given , and convulsions. One of the major metabolites of trazodone, meta-chlorophenylpeperazine m-CPP , has serotonergic effects and may contribute to serotonin syndrome confusion delirium, hyperreflexia, autonomic instability when trazodone is used in combination with other serotonergic agents. Use in hepatic impairment Dosage reduction may be required in patients with hepatic impairment see Special warnings and special precautions for use.
Low-dose doxepin 3 mg and 6 mg has demonstrated efficacy for insomnia characterized by frequent or early-morning awakenings and an inability to return to sleep Table 1. Limit your time in the sun. They are available as over the counter products. They are cheaper and well studied drugs. Doxepin is extensively metabolized to N-desmethyldoxepin which is a biologically active metabolite and other inactive metabolites.
The pros and cons of low dose doxepin in insomnia are well evaluated.
Ask your doctor before use if you are taking the following medications:
It increases the effects of caffeine and can make you very jittery and nervous.
Bisphosphonates may cause GI adverse events and occasionally, renal dysfunction.
Serious adverse events occurred infrequently and the rates of such events were similar in both treatment groups.
Stay alert for indications of fluid imbalance.
After my last hospitalization, I was put on Advair, and I am concerned with some of the warnings about this drug.
If you have questions about the medicines you are taking or would like more information, check with your doctor, pharmacist, or nurse. Antidepressants are medicines used to treat depression and other illnesses. In Fundamentals of Monitoring Psychoactive Drug Therapy.