Citalopram is associated with dose dependent QT interval prolongation.
In vitro studies show that citalopram is at least 8 times more potent than its metabolites in the inhibition of serotonin reuptake, suggesting that the metabolites evaluated do not likely contribute significantly to the antidepressant actions of citalopram.
Do not take Citalopram Sandoz to treat any other complaints unless your doctor tells you to.
Patients randomly assigned to 40 mg day and 60 mg day of citalopram showed significantly greater improvement than placebo on all efficacy measures, as well as on the HAM-D symptom clusters measuring depressed mood, melancholia, cognitive disturbance, and psychomotor retardation.
Unlike the tricyclic antidepressants, citalopram has minimal anticholinergic effects. If you have any questions, ask your doctor or pharmacist. Important safety information about the potential for QT interval prolongation and Torsade de Pointes with drug dosage and usage recommendations are being added to the package inserts of Celexa and its generic equivalents.
The onset of action for depression is approximately 1 to 4 weeks. Advise patients on citalopram to contact a healthcare professional immediately if they experience signs and symptoms of an abnormal heart rate or rhythm e.
Details Cytochrome P450 2C19 CYP2C19 24 Not Available 99C T 991A G show all ADR Inferred Poor drug metabolizer, increased risk of QT prolongation.
Ask your doctor before use if you are taking the following medications:
If symptomatic hypotension occurs, initiate supportive treatment.
Congo hemorrhagic fever epidemics often occur in areas where health services are limited, and result in high case fatality rates.
Among the 16 patients with ALT activity at least twice the ULN, most of the high values were isolated and transient or reversible following treatment discontinuation.
Be careful if you drive or do anything that requires you to be alert. Citalopram HBr is sparingly soluble in water and soluble in ethanol. The effect of citalopram when taken by people with severely decreased kidney function has not been well studied. This drug is used to treat depression.