The risk of seizures with bupropion is dose related and is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold.
Bupropion can cause you to have a false positive drug screening test.
However, interpretation is once again restricted due to the dearth in research within this population and notable methodological issues including a small sample size and absence of a placebo group. Positive results were seen in bipolar depression, older adults, SAD and dysthymia, but cons. Two early studies employed more rigorous, and similar, methodological designs.
Other rarely reported side effects included restlessness, anxiety, constipation, dizziness, nasopharyngitis and fatigue. Dosage Forms may administer as divided doses for safety and effectiveness eg, BID for children and TID for adolescents. Following on from this, depressive disorders are becoming ever more to be seen as fundamentally heterogeneous conditions with as yet incompletely understood but highly complex pathway disorders involving numerous gene and environmental interactions Koutsouleris et al.
A large n 785 RCT by Clayton and colleagues randomized participants to receive bupropion XL 300 450 mg day, n 276 , escitalopram 10 20 mg day, n 281 or placebo n 273 Clayton et al.
Ask your doctor before use if you are taking the following medications:
This drug may increase your risk of liver problems.
HT from the enterochromaffin cells within the mucosa to trigger vagus nerve firing to initiate the emetic reflex.
There is evidence that it can reduce measures of sexual dysfunction, thereby resulting in a rise in sexual desire and related measures. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants. CYP2D6 isoenzyme, such as promethazine, should be approached with caution.
There are no known antidotes for bupropion. Consult your pharmacist or local waste disposal company. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.