Here are some key points about aripiprazole.
Aripiprazole exhibited antagonist properties in animal models of dopaminergic hyperactivity and agonist properties in animal models of dopaminergic hypoactivity.
Anyone considering the use of adjunctive aripiprazole or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.
Table 19 Commonly Observed Adverse Reactions in Short- Term, Placebo-Controlled Trials of Pediatric Patients 10 to 17 years with Bipolar Mania Treated with Oral ABILIFY Preferred Term Percentage of Patients Reporting Reaction ABILIFY n 197 Placebo n 97 Somnolence 23 3 Extrapyramidal Disorder 20 3 Fatigue 11 4 Nausea 11 4 Akathisia 10 2 Blurred Vision 8 0 Salivary Hypersecretion 6 0 Dizziness 5 1.
The possibility of a suicide attempt is inherent in psychotic illnesses, bipolar disorder, and major depressive disorder, and close supervision of high-risk patients should accompany drug therapy. Administration of a 15 mg ABILIFY Tablet with a standard high-fat meal did not significantly affect the Cmax or AUC of aripiprazole or its active metabolite, dehydro-aripiprazole, but delayed Tmax by 3 hours for aripiprazole and 12 hours for dehydro-aripiprazole.
Your doctor may need to adjust your diabetes medication, exercise program, or diet. Adverse Reactions in Long-Term, Double-Blind, Placebo-Controlled Trials. What should I do if I forget a dose. In two pharmacokinetic studies of aripiprazole injection administered intramuscularly to healthy subjects, the median times to the peak plasma concentrations were at 1 hour and 3 hours. Are there any possible s We use medicines to make our children better, but sometimes they have other effects that we don t want side-effects.
Because ABILIFY was not marketed at the time these studies were performed, it is not known if ABILIFY is associated with this increased risk.
Ask your doctor before use if you are taking the following medications:
Females, elderly patients, patients with diabetes mellitus, thyroid disease, malnutrition, alcoholism, or hepatic dysfunction may also be at increased risk for QT prolongation.
It may cause very bad and sometimes deadly side effects like other types of abnormal heartbeats.
In some children and teenagers, treatment with an antidepressant increases suicidal thinking or actions.
Conjugated estrogens may cause an increase in the curvature of the cornea.
Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope. Properly discard this product when it is expired or no longer needed. May increase risk of suicidal tendencies in children and adolescents.