As I said, I can only say positive things about Amitriptyline.
Amitriptyline probably does provide good levels of pain relief for some people with fibromyalgia, although we cannot be certain of this.
If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy.
Electrolyte disturbances hypokalaemia, hyperkalaemia, hypomagnesaemia are known to be conditions increasing the proarrhythmic risk. Your doctor will probably recommend reducing your dose gradually over several weeks - or longer, if you have been taking amitriptyline for a long time. These are warning signs of a serious allergic reaction. Consider a 50 reduction of the recommended starting dose.
Careful dosing and, if possible, a serum level determination is advisable.
Ask your doctor before use if you are taking the following medications:
These changes may result in increased adverse events, or delayed or more rapid onset of activity, depending upon the nature of the switch.
Advise patients that the use of some vaccines should be avoided during treatment and for at least 6 months after discontinuation.
Amitriptyline may increase the effects of other drugs that may cause drowsiness, including other antidepressants, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants.
There were no consistent differences between amitriptyline and placebo or other active comparators for relief of symptoms such as fatigue, poor sleep, quality of life, or tender points. Ask your doctor or pharmacist for more information. Canada residents can call a provincial poison control center. Some young people have thoughts about suicide when first taking an antidepressant. Amitriptyline HCl, a dibenzocycloheptadiene derivative, has a molecular weight of 313.