Plasma clearance of topiramate is unchanged in elderly subjects in the absence of underlying renal disease.
The five side effects that were most likely to cause people to discontinue use of Topiramate were psychomotor slowing, fatigue, memory problems, confusion, and somnolence.
Try to avoid drinking alcohol, as this will make you feel more tired. Your doctor will probably start you on a low dose of topiramate and gradually increase your dose, not more than once every week. This medication can rarely cause a serious metabolic problem high amount of ammonia in the blood , especially if you are also taking valproic acid.
RESULTS Four hundred eighty-seven patients were randomized, and 469 composed the intent-to-treat population. OBJECTIVE To assess the efficacy and safety of topiramate as a migraine-preventive therapy.
Ask your doctor before use if you are taking the following medications:
Pharmacologic treatment should be used only after giving adequate attention to correction of modifiable contributing factors.
This combination apparently increases the risk for adverse events and is therefore not recommended.
In case combination treatment is necessary blood cell count and the renal function should be monitored.
Due to the potential for hepatotoxicity, monitoring of aminotransferase levels is recommended at baseline and 1 month after maximum dose is achieved, or if hepatic injury is suspected.
Taking topiramate with metformin may put you at risk for certain side effects. Please refer to our terms and conditions. This drug may make you dizzy or drowsy or impair your judgment. Occasionally, a medication used to treat one condition is found to have effects on other conditions.