Do not drive a car or operate heavy machinery until you know how topiramate affects you.
Absorption of Topiramate is rapid, with peak plasma concentrations occurring at approximately 2 hours following a 400 mg oral dose.
There are no known interactions between Topiramate and lithium. More concerning is the drug s potential for causing behavioral or cognitive disturbance, the latter typically manifested by impaired recent memory, impaired concentration, or word-finding difficulties. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.
If your child is sick less than 30 minutes after having a dose of topiramate, give them the same dose again. For example, if you usually give a dose at 7 am, you can give the missed dose at any time up to 11 am. While the clinical trials for migraine prevention that earned topiramate its FDA approval involved patients with episodic migraine ie, less than 15 headache days per month , 1 large, randomized, placebo-controlled study indicated that topiramate may be effective for patients with chronic migraine as well ie, 15 or more headache days per month.
A research study that compared 711 participants taking Topiramate and 419 taking a placebo observed the following sets of side effects in both groups Common Adverse Reactions. Tell your doctor straight away if you. The incidence of some adverse reactions e.
Ask your doctor before use if you are taking the following medications:
RTV used to boost PI concentration did not appear to alter the risk of liver injury beyond that of the parent PI.
Cordarone increases the cardiac refractory period without influencing resting membrane potential, except in automatic cells where the slope of the prepotential is reduced, generally reducing automaticity.
Placebo Patients with Events per 1000 Patients. Ask your healthcare provider if you are not sure if your medicine is listed above.
You can easily become dehydrated while taking this medication. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor. The clinical significance of this change is unknown. Because of the way topiramate acts in the body, starting in about 2004, the drug was tested for and has shown promise in various uses in addiction treatment.