Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract.
Divalproex sodium can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.
Increased liver function tests, which the investigator considered an adverse event, contributed to the premature discontinuation of three patients in the divalproex group and two patients in the placebo group.
Animal studies show risk and human studies not available or neither animal nor human studies done. Selected from data included with permission and copyrighted by First Databank, Inc. Some of these include hepatic enzyme-inducing drugs, aspirin, carbapenem antibiotics, diazepam, ethosuximide, lamotrigine, phenytoin, amitriptyline, nortriptyline, warfarin, zidovudine, and topiramate. If you need to take these drugs together, your doctor will likely decrease your dosage of propofol.
Child dosage ages 0 to 17 years. All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment. If you re taking these drugs together, your doctor should monitor your blood ammonia levels and temperature.
Migraine headache prevention in women who are pregnant or plan to become pregnant.
Ask your doctor before use if you are taking the following medications:
Corticosteroids should be used with caution, if at all, in patients with active or quiescent tuberculous infection of the respiratory tract, or in untreated fungal, bacterial, systemic viral infections, or ocular herpes simplex because of the potential for worsening of these infections.
Patients on chronic steroid therapy should wear Medic Alert bracelet.
Excess hair growth on the face, back, arms, and legs Increased swelling of the face, hands, or ankles Mouth sores Stomach irritation or ulcers Mood swings and depression Joint pain and muscle weakness Increased risk of infection Increased risk of developing osteoporosis.
Serum barbiturate concentrations should be obtained, if possible, and the barbiturate dosage decreased, if appropriate. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. If you do forget complete take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose.
Above the age of 2 years, experience in epilepsy has indicated that the incidence of fatal hepatotoxicity decreases considerably in progressively older patient groups. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.