The safety of clarithromycin during pregnancy and breast feeding of infants has not been established.
The most frequent and common adverse reactions related to clarithromycin therapy for both adult and peadiatric populations are abdominal pain, diarrhoea, nausea, vomiting and taste perversion.
Other medications can affect the removal of clarithromycin from your body, which may affect how clarithromycin works. In two studies in which theophylline was administered with clarithromycin a theophylline sustained- release formulation was dosed at either 6. While the extent of formation of 14-OH clarithromycin following administration of clarithromycin extended-release tablets 2 500 mg tablets once daily is not affected by food, administration under fasting conditions is associated with approximately 30 lower clarithromycin AUC relative to administration with food.
John s Wort Use With Caution There have been spontaneous or published reports of CYP3A based interactions of clarithromycin with alfentanil, methylprednisolone, cilostazol, bromocriptine, vinblastine, phenobarbital, and St. There are no data available on cerebrospinal fluid penetration.
It might help to take your clarithromycin after you have had a meal or snack. It will not work for viral infections such as common cold, flu. Drug interactions may change how your medications work or increase your risk for serious side effects.
Ask your doctor before use if you are taking the following medications:
As folic acid requirements are also increased during pregnancy, regular screening of patients at risk is advised, and treatment with folic acid and Vitamin B12, although controversial, should be considered.
Not all risks may pertain to all patients.
The 1000 mg and 2000 mg twice daily doses showed significantly better control of bacteremia during the first four weeks of therapy. As with other macrolides, clarithromycin serum concentrations are not expected to be appreciably affected by hemodialysis or peritoneal dialysis.
Some patients have shown clinical signs consistent with digoxin toxicity, including potentially fatal arrhythmias.