In this review the recent discovery that chloroquine and related quinolines inhibit the novel heme polymerase enzyme that is also present in the trophozoite food vacuole is introduced.
Chloroquine also binds to ferriprotoporphyrin IX and this leads to lysis of the plasmodial membrane.
If the victim has collapsed, had a seizure, has trouble breathing, or can t be awakened, immediately call emergency services at 911. There have been rare reports of severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome, toxic ep.
Talk to your doctor about the possible risks of using this drug for your condition. The key molecular determinants of chloroquine resistance involve a number of mutations in the so-called chloroquine resistance transporter gene, or pfcrt. Ask your pharmacist any questions you have about refilling your prescription. Chloroquine is considered safe in pregnancy and in young children. Adults An initial dose of 1 g 600 mg base followed by an additional 500 mg 300 mg base after six to eight hours and a single dose of 500 mg 300 mg base on each of two consecutive days.
What else should I know about this medication. Weber-Christian disease is a rare inflammatory disease that affects the body s fat tissues.
Ask your doctor before use if you are taking the following medications:
If concomitant therapy is necessary, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine kinase should be monitored.
This drug can cause new mental health and behavior problems.
Although the data associating PfCRT mutations and chloroquine resistance are strong, they do not prove causality, and additional evidence for the central role of PfCRT in resistance has been required. Slightly more than half of the urinary drug products can be accounted for as unchanged chloroquine. Store at room temperature away from moisture and heat.
Do not let anyone else take your medication.