The usual dose of donepezil is 5 mg once a day.
The potential for donepezil hydrochloride to alter the course of the underlying neuropathology has not been studied.
The range of patient exposure was from 1 to over 500 days. Table 1 Most Common Adverse Reactions Leading to Discontinuation in Patients with Mild to Moderate Alzheimer s Disease Adverse Reaction Placebo n 355 5 mg day ARICEPT n 350 10 mg day ARICEPT n 315 Nausea 1 1 3 Diarrhea 0.
For patients randomized to ARICEPT, treatment was initiated at 5 mg once daily for 28 days and then increased to 10 mg once daily. Therapy with donepezil should only be started if a caregiver is available who will regularly monitor medicinal product intake for the patient. Figure 6 is a histogram of the frequency distribution of CIBIC-plus scores attained by patients assigned to each of the three treatment groups who completed 12 weeks of treatment.
If you are taking the 23-milligram strength tablets, swallow them whole. Donepezil treatment in severe Alzheimer s disease a pooled analysis of three clinical trials.
Ask your doctor before use if you are taking the following medications:
Parents and caregivers should be informed to contact their physician if vomiting or irritability with feeding occurs.
Do not use within 1 hour after taking an antacid or milk.
Ask your doctor if you have risk factors for arrhythmias.
These drugs and donepezil work in opposite ways. If you become pregnant while taking this drug, call your doctor right away. The rapidly disintegrating tablet should be placed on the tongue and allowed to dissolve before swallowing with water.
AChEIs on AChE and BuChE activity in normal human brain cortex.