These drugs and donepezil work in opposite ways.
Donepezil can be taken with or without food or milk.
Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications.
Although donepezil was originally developed to inhibit the breakdown of the neurotransmitter acetylcholine as symptomatic therapy for AD, recent studies raise the possibility of other effects this drug has on the pathogenesis of AD.
Dementia may cause impairment of driving performance or compromise the ability to use machinery. Do not stop taking it unless your doctor instructs you to do so. Donepezil is absorbed slowly, but completely, from the gut, reaching peak plasma levels in 3-4 h and, with daily dosing, steady-state concentration in 15-21 days.
You may need to start at a lower dose to decrease the risk of side effects.
Ask your doctor before use if you are taking the following medications:
Although encouraging, these modifications in surrogate endpoints do not substitute for clinical outcomes such as effect on coronary death and nonfatal myocardial infarction.
Closer liason between the day ward and the menopause clinic might have resulted in more successful counselling of these women, particularly in the earlier months of the study, and thus a more acceptable discontinuation rate.
Although causality for TdP has not been established for flecainide, patients receiving concurrent drugs which have the potential for QT prolongation may have an increased risk of developing proarrhythmias.
ARICEPT in a controlled clinical trial that compared the two doses. Call your doctor for medical advice about side effects. If you notice the symptoms of NMS, get immediate medical attention.