Azelastine has an active metabolite, desmethylazelastine, which probably extends the duration of action of the drug.
You should not use this medicine if you are allergic to azelastine.
In fact, azelastine nasal spray was superior to desloratadine tablets at alleviating nasal congestion when comparing absolute scores at the end of the challenge.
This medicine usually begins working within 3 hours of use. In 5 comparisons azelastine was more efficacious than placebo with a summary NNT of 5.
Leukotriene B4 production by blood neutrophils in allergic rhinitis effects of cetirizine. Inhibition of leukotriene synthesis by azelastine. PubMed Google Scholar Zechel HJ, Brock N, Lenke D, et al. Use of nasal steroids in managing allergic rhinitis. In Canada - Call your doctor for medical advice about side effects. Therefore, these results suggest that azelastine at a dosage of 1 spray per nostril is just as effective as 2 sprays. Google Scholar Berger W, Hampel F, Bernstein J, et al.
Ask your doctor before use if you are taking the following medications:
If you have a history of blood clots, including in the legs, lungs, or eyes, taking this medication may increase the risk of getting blood clots.
Once the CADR had resolved and laboratory parameters returned to baseline, we initiated three SLDs to which the patient had not previously been exposed as bridging therapy.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
The bottle should be discarded after 200 sprays have been used. Azelastine HCl, USP occurs as a white, almost odorless, crystalline powder with a bitter taste. There was also no difference in treatment effect between patients with perennial allergic rhinitis only compared to those with perennial allergic rhinitis and concomitant seasonal allergic rhinitis.
Azelastine nasal spray is well tolerated in both adults and children with allergic rhinitis.