Ointment contains tacrolimus, a macrolide immunosuppressant produced by Streptomyces tsukubaensis.
We did not find any evidence associating a risk of malignancies with the use of topical tacrolimus.
Tacrolimus Sandoz, which had been approved as safe and effective by Medsafe, emerged as a potential alternative to Prograf.
The lowest tacrolimus blood concentration at which systemic effects can be observed is not known.
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