The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity and increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium.
Hydrochlorothiazide is the second most commonly prescribed antihypertensive in the United States.
When given concurrently the following drugs may interact with thiazide diuretics. Few subjective side effects were reported. In published studies, clinically significant hypokalemia has been consistently less common in patients who received 12.
A few studies that included combinations with potassium-sparing diuretics were considered secondary sources of data, because several studies demonstrated that neither amiloride nor triamterene added to the antihypertensive effects of HCTZ or chlorthalidone.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. In an 87 patient 4-week double-blind, placebo controlled, parallel group trial, patients who received MICROZIDE hydrochlorothiazide capsule had reductions in seated systolic and diastolic blood pressure that were significantly greater than those seen in patients who received placebo.
Ask your doctor before use if you are taking the following medications:
Because dietary fat is high in calories, this leads to fewer calories being processed by the body, which can lead to weight loss.
You should stop taking the pill four weeks before your operation to avoid an increased risk of blood clots.
To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise.
Since bradycardia is a risk factor for development of TdP, the potential occurrence of bradycardia during octreotide administration could theoretically increase the risk of TdP in patients receiving drugs that prolong the QT interval.
Cigarette smoking is a major cause of morbidity in patients with asthma and has been shown to be independently associated with impaired quality of life in asthmatic children.
Exactly how chloride transport is impaired is unknown. Pitting edema is scored on pitting edema measurement scales. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide.
It is important that this medication be taken exactly as prescribed by your doctor. This is not a complete list of side effects that can occur with hydrochlorothiazide.