In separate single or multiple dose pharmacokinetic interaction studies with chlorthalidone, nifedipine, propranolol, hydrochlorothiazide, cimetidine, metoclopramide, propantheline, digoxin, and warfarin, the bioavailability of fosinoprilat was not altered by coadministration of fosinopril with any one of these drugs.
Following oral administration, fosinopril is rapidly and completely hydrolyzed to its principle active metabolite, fosinoprilat.
In those cases which were possibly related to fosinopril therapy, the elevations were generally mild and transient and resolved after discontinuation of therapy.
This prodrug strategy was used to improve the bioavailability of oral enalapril from 3 12 percent to 60 70 percent for the ester enalaprilat, which resembles the structure of the tripeptide Phe-Ala-Pro. Before using this medication, tell your doctor or pharmacist your medical history, especially of history of an allergic reaction which included swelling of the face lips tongue throat angioedema , blood filtering procedures such as LDL apheresis, dialysis , high level of potassium in the blood.
Tell your doctor right away if you notice any of the following rare but serious side effects yellowing eyes skin, dark urine, severe stomach abdominal pain, persistent nausea vomiting. In the patients treated with fosinopril sodium, the adverse effects were in general mild and transient.
The reason for their efficacy in patients with low PRA is less clear, but this may be due to inhibition of intrarenal angiotensin II formation. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Dosage Forms affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and or death.
Ask your pharmacist for a list of the ingredients.
Ask your doctor before use if you are taking the following medications:
Use only the prescribed dose of this medication, and do not use it for longer than your doctor recommends.
Do not use the inhalation solution if it is discoloured.
For maintenance therapy, the lowest effective dose should be used.
It helps prevent your body from absorbing too much salt, which can cause fluid retention.
In such cases emergency therapy should be administered promptly. Older adults may be more sensitive to the side effects of this drug, including dizziness and increases in potassium level. The blood pressure reduction might be progressive and several can be required to obtain the therapeutic effect.
Select a symptom, answer some questions, get advice. These are not all of the side effects that may occur. The resulting reduction in angiotensin II levels leads to alternative reduction in vasoconstriction and a decrease in aldosterone secretion, that might induce a slight increase in serum potassium and a loss of sodium and fluid.