Insulin resistance is an impaired biological response of body tissues to the action of insulin. And it does not matter where the insulin comes from, from the own pancreas (endogenous) or from injections (exogenous).
Insulin resistance not only increases the likelihood of type 2 diabetes, but also atherosclerosis, a heart attack, and sudden death due to a blockage of the vessel with a blood clot.
The effect of insulin is in the regulation of metabolism (not only carbohydrates, but also fats and proteins), as well as mitogenic processes - this is growth, cell multiplication, DNA synthesis, gene transcription.
The modern concept of insulin resistance is not limited only to impaired carbohydrate metabolism and an increased risk of type 2 diabetes. It also includes changes in the metabolism of fats, proteins, gene expression. In particular, insulin resistance leads to problems with endothelial cells that cover the inside of the walls of blood vessels. Because of this, the lumen of blood vessels narrows, and atherosclerosis progresses.
You may be suspicious of insulin resistance if symptoms and / or tests show that you have metabolic syndrome. It includes:
Abdominal obesity is the main symptom. In second place is arterial hypertension (high blood pressure). It rarely happens that a person does not have obesity and hypertension, but blood tests for cholesterol and fats are already bad.
Diagnosing insulin resistance with the help of analyzes is problematic. Because the concentration of insulin in the blood plasma can vary greatly, and this is normal. In the analysis of insulin in fasting blood plasma, the norm ranges from 3 to 28 μED / ml. If insulin in the blood on an empty stomach turns out to be above the norm, then the patient has hyperinsulinism.
An increased concentration of insulin in the blood occurs when the pancreas produces an excess amount of it to compensate for tissue insulin resistance. This result indicates that the patient has a significant risk of type 2 diabetes and / or cardiovascular disease.
The exact laboratory method for determining insulin resistance is called hyperinsulinemic insulin clamp. It involves continuous intravenous administration of insulin and glucose for 4-6 hours. This is a laborious method, and therefore it is rarely used in practice. Limited to fasting blood analysis for plasma insulin
Studies have shown that insulin resistance occurs:
When you donate a blood test for cholesterol - check not total cholesterol, but separately “good” and “bad”.
Normally, an insulin molecule binds to its receptor on the surface of muscle cells, adipose tissue, or liver tissue. After this, insulin receptor autophosphorylation takes place with the participation of tyrosine kinase and its subsequent connection with the substrate of insulin receptor 1 or 2 (IRS-1 and 2).
In turn, the molecules of IRS activate phosphatidylinositol-3-kinase, which stimulates the translocation of GLUT-4. It is a carrier of glucose into the cell through the membrane. This mechanism provides the activation of metabolic (glucose transport, glycogen synthesis) and mitogenic (DNA synthesis) insulin effects.
Note that insulin blocks the breakdown of adipose tissue. That is why, if the level of insulin in the blood is elevated (hyperinsulinism is a frequent occurrence with insulin resistance), then it is very difficult, almost impossible to lose weight.
Insulin resistance is the problem of a huge percentage of all people. It is believed that it is caused by genes that have become predominant in the course of evolution. In 1962, they hypothesized that this is a survival mechanism during a long famine. Because it enhances the accumulation of fat reserves in the body during periods of abundant nutrition.
Scientists subjected mice to starvation for a long time. The longest survived were those individuals in whom genetically mediated insulin resistance was found. Unfortunately, in modern people, the same mechanism “works” for the development of obesity, hypertension and type 2 diabetes.
Studies have shown that patients with type 2 diabetes have genetic defects in signal transmission after insulin is connected to its receptor. This is called postreceptor defects. First of all, translocation of the glucose transporter GLUT-4 is impaired.
In patients with type 2 diabetes, impaired expression of other genes that metabolize glucose and lipids (fats) has also been found. These are the genes for glucose-6-phosphate dehydrogenase, glucokinase, lipoprotein lipase, fatty acid synthase, and others.
If a person has a genetic predisposition to develop type 2 diabetes, then it may or may not result in metabolic syndrome and diabetes. It depends on the lifestyle. The main risk factors are excessive nutrition, especially the consumption of refined carbohydrates (sugar and flour), as well as low physical activity.
For the treatment of diseases, insulin sensitivity of muscle and adipose tissue, as well as liver cells, is of the greatest importance. But is the insulin resistance of these tissues the same? In 1999, experiments showed no.
Normally, in order to suppress lipolysis by 50% (fat breakdown) in adipose tissue, insulin concentrations in the blood are sufficient to be no higher than 10 μED / ml. For 50% suppression of glucose release into the blood by the liver, about 30 μU / ml of insulin in the blood is required. And in order for glucose uptake by muscle tissue to increase by 50%, an insulin concentration in the blood of 100 μED / ml and higher is needed.
We remind you that lipolysis is the breakdown of adipose tissue. The action of insulin inhibits it, as does glucose production by the liver. And the seizure of glucose by muscles under the influence of insulin increases. Note that in type 2 diabetes mellitus, the indicated values of the required concentration of insulin in the blood are shifted to the right, i.e., towards an increase in insulin resistance. This process begins long before diabetes manifests itself.
The sensitivity of body tissues to insulin is reduced due to genetic predisposition, and most importantly - because of an unhealthy lifestyle. In the end, after many years, the pancreas ceases to cope with increased stress. Then they diagnose “real” type 2 diabetes. The patient is greatly benefited if the treatment of the metabolic syndrome is started as early as possible.
You should know that insulin resistance occurs in people and other health problems that are not included in the concept of “metabolic syndrome”. It:
Insulin resistance sometimes develops during pregnancy, and after childbirth - passes. It also usually rises with age. And it depends on what kind of lifestyle an elderly person leads to, whether it will cause type 2 diabetes and / or cardiovascular problems. In the article “Diabetes in the elderly” you will find a lot of useful information.
In type 2 diabetes mellitus, insulin resistance of muscle cells, liver and adipose tissue is of the greatest clinical significance. Due to the loss of insulin sensitivity, less glucose enters and “burns out” in muscle cells. In the liver, for the same reason, the process of glycogen decomposition to glucose (glycogenolysis) is activated, as well as the synthesis of glucose from amino acids and other “raw materials” (gluconeogenesis).
Insulin resistance of adipose tissue is manifested in the fact that the anti-lipolytic effect of insulin weakens. At first, this is offset by increased insulin production by the pancreas. In the later stages of the disease, more fat breaks down into glycerol and free fatty acids. But during this period, losing weight does not bring much joy.
Glycerol and free fatty acids enter the liver, where very low density lipoproteins are formed from them. These are harmful particles that are deposited on the walls of blood vessels, and atherosclerosis progresses. Also from the liver in the bloodstream enters an excess amount of glucose, which appears as a result of glycogenolysis and gluconeogenesis.
Symptoms of metabolic syndrome in humans precede the development of diabetes. Because insulin resistance has been compensated for many years by excessive insulin production by beta cells of the pancreas. In this situation, there is an increased concentration of insulin in the blood - hyperinsulinemia.
Hyperinsulinemia with a normal level of glucose in the blood is a marker of insulin resistance and a precursor of the development of type 2 diabetes. Over time, the beta cells of the pancreas no longer cope with the load, which is several times higher than normal. They produce less insulin, the patient's sugar level in the blood rises and diabetes is manifested.
First of all, the 1st phase of insulin secretion suffers, i.e. the rapid release of insulin into the blood in response to the food load. And the basal (background) insulin secretion remains excessive. When the blood sugar level rises, it further enhances the insulin resistance of tissues and inhibits the function of beta cells by insulin secretion. This mechanism of diabetes is called “glucose toxicity.”
It is known that in patients with type 2 diabetes, cardiovascular mortality increases by 3-4 times, compared with people without metabolic disorders. Now more and more scientists and medical practitioners are convinced that insulin resistance and, along with it, hyperinsulinemia is a serious risk factor for heart attack and stroke. Moreover, this risk does not depend on whether the patient has developed diabetes or not.
Since the 1980s, studies have shown that insulin has a direct atherogenic effect on the walls of blood vessels. This means that atherosclerotic plaques and the narrowing of the vascular lumen are progressing under the action of insulin in the blood that flows through them.
Insulin causes the proliferation and migration of smooth muscle cells, the synthesis of lipids in them, the proliferation of fibroblasts, activation of the blood coagulation system, a decrease in the activity of fibrinolysis. Thus, hyperinsulinemia (increased concentration of insulin in the blood due to insulin resistance) is an important cause of atherosclerosis. This happens long before the onset of type 2 diabetes in a patient.
Studies show a clear direct relationship between excess insulin and risk factors for cardiovascular diseases. Insulin resistance leads to the fact that:
This stable relationship has been proven both in patients with type 2 diabetes and in those without it.
An effective method of treating insulin resistance in the early stages of type 2 diabetes, and even better before it develops, is a diet with restriction of carbohydrates in the diet. To be precise, this is not a way of treatment, but only of control, restoring balance with impaired metabolism. Low-carbohydrate diet with insulin resistance - it must be followed for life.
After 3-4 days of switching to a new diet, most people notice an improvement in their state of health. After 6-8 weeks, tests show that the “good” cholesterol in the blood rises and the “bad” drops. The level of triglycerides in the blood drops to normal. Moreover, this happens after 3-4 days, and cholesterol tests improve later. Thus, the risk of atherosclerosis is reduced several times.
Recipes for low-carbohydrate diets versus insulin resistance are available here.
There are currently no methods for real treatment of insulin resistance. Experts in the field of genetics and biology are working on this. You can control this problem well by eating a low-carb diet. First of all, you need to stop eating refined carbohydrates, that is, sugar, sweets and white flour products.
Metformin gives good results (siofor, glucofage). Use it in addition to the diet, and not instead of it, and first consult your doctor about taking pills. Every day we follow the news in the treatment of insulin resistance. Modern genetics and microbiology work wonders. And there is hope that in the coming years they will be able to finally solve this problem. Want to find out first - subscribe to our newsletter, it's free.
I would like to receive comments on my problem.
Age 56 years, height 168, weight 90, no diabetes, but there is insulin resistance.
Increased pressure 150/100
I accept only VOGLIBOSE, Plendil, Korsal, Reduxin Light and Reduxin, 2 liters of clean water on an empty stomach every day.
I have been living and working permanently in China for 10 years, the examination took place in the hospital of the University of San Etsin. The treatment and diagnosis was carried out according to the latest approved methods of the international medical organization.
Losing weight and normalizing with acupuncture, low carbon nutrition.
7 years ago in the same way I lost 20 kg, I gained weight before the previous one in 7 years. Now I am doing the same procedure and losing 200 g every day again.
I wanted to cure insulin resistance and maintain health for the rest of my life. Are there any new ways or are in development?
I would like to receive your comments. If you have questions about treatment in China, I will be glad to answer. thank
> Are there any new ways?
> or are in development?
Read our article "How to reduce blood sugar." Carefully stick to a low-carb diet as prescribed. This is guaranteed to help insulin resistance. I also recommend studying the book “Younger Every Year” - http://diabet-med.com/inform/. Perhaps she will inspire you to do some physical activity.
Hello! I am 44 years old. She decided for herself to pass blood tests prophylactically. And to my surprise, she received the following results: glucose - 8.6 mmol / l (the norm is up to 5.9), insulin - 18.2 μME / ml (the norm is 6 - 29.1), HOMA-IR index - insulin resistance assessment - 6 , 96 (up to 2.7), HbA1c - 9.2% (normal 4.8 - 5.9).
Very upset by these results. I have no increased thirst, there is no frequent urination either.
What to do? Does this mean you need to switch to insulin injections?
I am overweight, I take Lozap from high blood pressure.
Thank you for the expected help.
You have "full" type 2 diabetes. If you are not treated, you are unlikely to live to 55 years. Not later than in 5 years (rather, much earlier) I guarantee problems with my legs, eyesight and kidneys. If a heart attack or stroke does not kill you before, then renal failure will kill you.
> Need to switch to insulin injections?
It depends on how carefully you follow the diet and exercise, and what results all this will give.
You need to read a low-carb diet to control diabetes and stick to it diligently. A low-carb diet is your new religion. Her observance must subordinate everything else if you want to live a normal life.
Read the sources of information that we use and exercise with pleasure. This tool is number 2 with a low-carbohydrate diet.
The first two weeks you need to diligently do all this and measure blood sugar with a glucometer several times a day. If he comes to normal values (after eating! On an empty stomach - not so important), then continue. If he still remains at least a little above the norm, then add the drug Siofor and for two more weeks continue the diet + physical education + Siofor.
And only if these three drugs do not help, then they will need to add insulin shots (how to do them painlessly) in low doses. In any case, all these activities several times (!) Reduce the dose of insulin that you will need. Compared to you, the rest of diabetics will prick themselves well, just horse dosage of insulin.
Best of all, as a physical education class, you will jog as described here. If you do this, then personally your chances of doing without insulin increase to 90-95%. Because age is still relatively young, and it is possible to slow down the development of diabetes.
Thank you so much for this site! I read a lot of literature, trying to understand what was happening to me wrong, but I didn’t see anything like it: very simple and easy to understand. I hope that you will save many lives. I arrange daily weekly starvation for myself, but at the exit of them (with raw vegetables and fruits, naturally), I had a lot of pain in my stomach, I was depressed and could not understand why my healthy lifestyle does not help me. I think your website will help not only diabetics, but also people who “plant” their bodies through a variety of diets, as well as your colleagues, who could not explain to me why my healthy cholesterol does not exceed my normal diet. The “vicious circle” scheme is especially good. I would add to it after p. 3 that the body begins to intensively produce adrenaline (as in Atkins), and this seriously affects our well-being.
> bad cholesterol rolls over
If so, then the low-carbohydrate diet should be combined with supplementation. The same Atkins has another great book, "Supplements." It contains a list of supplements that improve the cholesterol profile.
Thank you for the existence of this site and the possibility of receiving information from you in the form of competent answers (consultations).
I have impaired glucose tolerance and insulin resistance. Acquired (that is, the weight increased after 25 years, after stress, sedentary type of work). At the moment, 33 years old, height 158, weight 73 kg. Excess weight. Diets stand bad (or rather can not stand), drowsiness, lack of energy, working pressure is low (90/60).
The endocrinologist prescribed Siofor 850 and Glukobay. Siophor was nauseous and vomiting. Slightly reduced the dosage, added intense athletic load - and the weight began to decrease (plus a massage against cellulite), dropped about 5 kg.
I stopped drinking siofor and playing sports (as well as eating sweets) - I started to increase all over again. Feet freeze, frequent urination. Pregnancy does not occur 3 years.
After taking the siophore, my right side began to hurt, the load on the pancreas is felt.
In short, I was already desperate in everything, overweight is depressing, I do not see a way out of my situation.
I ask you to advise how to lose weight using a minimum of chemistry (drugs)? Or in my case it is impossible to lose weight without medication?
Thank you for your reply.
> how do I throw
> weight using a minimum of chemistry
You need to do the following:
1. Go on a low-carb diet.
2. Pass blood tests for thyroid hormones. There are 3 analyzes listed, take them all. The most important is T3 free. If it turns out that you have a deficiency of thyroid hormones - contact your endocrinologist, he will prescribe pills, take them. After 6 weeks, again pass the same tests, according to the results, change the dose of tablets. Then hold this event every 3 months.
3. Read the article physical culture with pleasure and enjoy how it is described.
> drowsiness, lack of energy, working
> low pressure (90/60). Cold feet
All these are signs of a deficiency of thyroid hormones, which is why I am sending you for tests and subsequent treatment. Just do not listen to the advice of an endocrinologist about what kind of diet you need to follow.
> Or in my case it is impossible
> lose weight without drugs?
You have a typical case, nothing special. Follow the recommendations listed above and it will work out.
Hello! Thank you so much for such an informative site, now much has become clear. Mom is diagnosed with type 2 diabetes for 7 years. 73 years old, height 156 cm, weight 50 kg, losing weight. All these years, she took diabeton pills, glucofaz, Novonorm, etc., and over the last month, she went off the scale - ranged from 12 to 20. She was eating wrong. The other day I passed the tests in the direction of the endocrinologist - in general, not so bad, they say. Increased cholesterol.
Total blood sugar control shows sugar spikes after eating. The lowest values in the morning on an empty stomach. With the help of a low-carbohydrate diet and taking syofor 850 an hour before breakfast and an hour before dinner, as well as glucofage 500 for the night, we managed to transfer sugar to corridor 9-11 without insulin. A few days ago, they were transferred to two-phase insulin Novomix 30: 15 units in the morning and evening. and Apidra 7 units for lunch. Insulin therapy started with 7 units of Novomiks in the morning and evening, plus siofor 850 before breakfast and dinner. Sugar remained within the same boundaries: 9-11. Gradually, the dose of insulin was brought to the prescribed 14 units in the morning and evening, but without pills the sugar rises - now in the corridor 10-13. In the morning on an empty stomach also the lowest rates of sugar per day. It seems that insulin does not work at all. Is it insulin resistance?
Today the doctor prescribed Novonorm for lunch instead of Apidra. Does this make sense? After all, it stimulates the production of short insulin and torments the pancreas - and without that exhausted. Extras: Mom has inflammation in the mouth. They wanted to go to treat, but sugar is high, it turns out a vicious circle. She also has hypothyroidism.
Tell me, please, what are the causes of insulin inefficiency? And what to do?
Thank you very much in advance.
> what could be the reasons
> insulin inefficiencies?
Learn the rules for storing insulin here, and then think about how well you follow them.
> Does this make sense?
There is no point in this, you understand correctly.
> height 156 cm, weight 50 kg, lose weight
> Is it insulin resistance?
Unfortunately, insulin resistance has nothing to do with it. Now your mother is slim. If, despite losing weight, sugar has not returned to normal, this means that type 2 diabetes has already passed into type 1 diabetes due to prolonged improper treatment. Diabeton and Novonorm tablets have done their dirty work. Therefore, you do not have to go through a type 2 diabetes treatment program, but study and implement a type 1 diabetes treatment program.
> She also has hypofunction of the thyroid gland.
Let the endocrinologist prescribe hormonal pills, and they need to be taken. With a high probability, it will become easier. Just do not listen to the advice of an endocrinologist about how to treat diabetes :).
> transferred to biphasic insulin Novomix
Mixed types of insulin is undesirable. If you buy for your money, it is better to prolong the insulin separately, and short separately.
What tests are needed to determine insulin resistance? 52 years old, weight 83 kg, height 167 cm. Thanks in advance.
> What tests need to pass,
> to determine insulin resistance?
Blood test for C-peptide, read more about it here.
> weight 83 kg, height 167 cm
With such indicators, you have insulin resistance, you can be sure, without any analyzes :). Go on a low-carbohydrate diet, exercise.
Mom has type 2 diabetes. Accepts mettophamma, metformin, depending on what is on sale. Sometimes in the morning the sugar is below the norm in terms of the meter, about 2-3. Usually around 7-8. What can it be and how harmful is it? Thanks in advance for your reply.
> What could it be
If you do not prick insulin and do not take other pills for diabetes, then this is not your exact blood glucose meter, lying. Buy a normal imported blood glucose meter.
Hello! Thank you for the useful information in an accessible form. From May 2012 there was a failure of menstruation - a delay of up to 2-3 months. I guess that was stress. The gynecologist-endocrinologist said that this could affect. After testing, it turned out that I have polycystic by ultrasound. Has handed over hormones - it turned out that they are ALL within the normal range. Yarina was appointed for half a year and Glucophage. Yarinu has been drunk, and Glucophage has not gone - the chair is upset, the intestines are constantly irritated, plus to that the contraindications in annotations are very terrible. I quit taking it in a month. It seems that the cycle has recovered, but the weight, which is already too excessive, began to grow further. In 2011, I weighed up to 83 kg with a growth of 167 cm, was always full. Today in my 25 years I weigh 103 kg. From the always active, cheerful girl I turn into a depressive phlegmatic matron. Today was on reception at the endocrinologist by results of analyzes: PCOS, grade 2 obesity, insulin resistance syndrome. Insulin on an empty stomach 16.82, after a meal-57.87! And dyslipidemia, although for her definition did not give anything extra. The doctor prescribed me a diet and metformin or siofor. Tell me, what are the risks for me when taking this drug on the background of polycystic. Pregnancy has never come yet, but we are planning with my husband a year or two later. Maybe I need some more tests to pass?
P.S. - always used to play sports with pleasure - at different times in different ways - running, fitness, aerobics, swimming - was plump, but taut, although she never lost weight below 70 kg. And now I have a sedentary lifestyle at all: sedentary work and protrusions of the lumbosacral spine. I almost always live with acute pain. Because of this, I can not once again even just take a walk! I understand that I have a risk of developing diabetes - I am very afraid of that!
And yet: the doctor prescribed the reception of metformin constant. Does this mean that I always now have to sit on these drugs. And their cancellation will not cause a deterioration in health. Or, after all, with the observance of prescriptions and losing weight, can I do without drugs?
Thanks in advance for your reply!
> very terrible contraindications in annotations
> what are the risks for me
> while taking this drug
There are no particular risks, these are practically no harmful pills.
> very upset chair,
> intestine constantly irritated
To avoid these side effects, read the article about Siofor and take the pill according to the scheme described there.
> Maybe I need some more tests to pass?
According to your description, hypothyroidism can be suspected - a lack of thyroid hormones. We need to pass these tests. It is strange that the doctor did not appoint them immediately.
> now I always have to sit on these drugs?
Rather, you have to sit on thyroid hormone pills.
Hello! Thank you so much for such an informative site!
I have a weight of 110 kg, height 176 cm, age 36 years. I do not have thirst, except very rarely, there is no frequent urination either. Glycosylated hemoglobin is 8.2%, fasting sugar is 8.2, and 2 hours after eating 16. The endocrinologist diagnosed type 2 diabetes. The question is, is there an effective treatment? Or today it all comes down to alleviating the symptoms and maintaining the state, when the harm done to the body by the disease is simply minimized? What can you advise in my case? The doctor prescribed Glucophage XR 1000 1 time per day. He started going to the pool shortly before visiting an endocrinologist, which has already led to a weight loss of 3 kg, as one of the obvious causes of diabetes. Based on what I read here, obesity is also a symptom, because it appeared after about 27-29 years. So, most likely, I also have insulin resistance. Lifestyle and sedentary work exacerbated the situation. Having read the insert from the drug package, it turned out that when it was prescribed, it would be nice to find out the function of the kidneys, which the doctor for some reason kept silent about.
> Is there an effective treatment?
> What can you advise in my case?
Follow a type 2 diabetes treatment program. If diet and physical education do not help, then quickly begin to prick insulin. Your sugar is very high. Therefore, with high probability, insulin will be needed.
> the doctor for some reason kept silent
You doctor to the bulb. He prescribed the pills and quickly kicked you off. Your health does not interest anyone but you.
Thank you for creating the site. Very affordable, concise and capacious presentation of the material. I saw a lot of what I knew. Much clarified where there were gaps, especially in the diet, learned new - vitamins, etc.
28 years old, 168 cm, 55 kg, insulin resistance, polycystic ovary.
From the very beginning of the first menstruation there was no regularity, gynecologists simply prescribed Diana-35 ... Found a good gynecologist-endocrinologist about 4 years ago. After testing, I prescribed Glucophage along with a low-carb diet, but failed. According to the endocrinologist, it was necessary to increase the dose, but I had a low weight and were afraid that I would lose weight and complications would go. Therefore, they appointed OK "Jess" to artificially maintain the cycle (since there was no ovulation) until I got ready to give birth. Already drink a few years and try to keep a diet. Can I now, taking Jess, pass tests and check the status of their disease? Or do you need to stop taking Jess? Do I need a blood glucose meter? Also interested in articles about polycystic ovaries.
> Can I take tests on taking Jess now?
> and check your illness?
Of course. Take insulin plasma on an empty stomach and tests for male sex hormones, check with your gynecologist. Although, as I understand it, it's not even an increased level of insulin. It may be normal. But the male sex hormones may be increased.
> Or do you need to stop taking Jess?
I do not know anything about this, consult a gynecologist.
> appointed OK "Jess"
> to artificially maintain the cycle
> until I can give birth
I read what Jess is. I'm afraid it will be difficult to get pregnant. While you are taking Jess, you will not be able to get pregnant, because these are contraceptive pills. And if you stop taking it, the cycle will break. However, this is not my topic at all. It is believed that while taking Glucophage, the chances of getting pregnant increase. Polycystic ovary increases the risk of type 2 diabetes with age. Here is its prevention - it is to us.
> Do I need a blood glucose meter?
Not yet. There is no financial strain, at the same time hand over a blood test for glycated hemoglobin. You have an increased risk of type 2 diabetes with age. In your place I would concentrate on not getting fat over the years, not losing shape. To do this, follow a low-carbohydrate diet (without fanaticism, that is, you can have some fruit, beets, carrots) and exercise.
> interested in articles about polycystic ovaries
If you know English, you can find the book Dr. Bernstein’s Diabetes Solution, there is an app about this metabolic disorder. But nothing really new in it. Follow the low-carbohydrate diet, take metformin (Glucophage or Siofor), exercise. Your gynecologist will prescribe other hormone pills that will increase your chances of getting pregnant. First, less powerful, and if they do not help, then incrementally. However, it is believed that they increase cancer risk. Therefore, too much to get involved in them is undesirable. 1-3 attempts - and that's enough. If I were you, I would already be interested in the issues of adoption and guardianship. The Internet is crammed with the stories of women who got pregnant only after they took 1-2 foster children.
Hello, my daughter (14 years old) was diagnosed with exogenous constitutional obesity, hyperinsulinemia. Analyzes were done: sugar curve, lipidogram - both are normal, sugar in the morning on an empty stomach - from 4.5 to 5.2. Insulin increased - 22.2 uU / ml at a rate of up to 17.
Ultrasound of the thyroid gland - a diffuse increase in the left lobe of the thyroid gland, signs of heterogeneous, hyperechoic tissue of the thyroid gland. Weight 88 kg with height 162 cm.
The endocrinologist recommended a diet for obesity (table 8) and metformin (siofor) - first, 500 mg per day, and then 1000, for a long time.
The question is: why is syofor recommended, which reduces sugar, if sugar is normal and there is no diabetes? And is it possible to refuse him, having tried to do the diet first?
It's a pity for a child to plant on such a toxic drug, all diabetics around are complaining that he is not well tolerated. Really nothing else came up with so far?
> why siofor recommended
No wonder recommended, in fact. Too lazy to write in detail.
> Is it possible to refuse it,
> having tried to do a diet first?
Can. Only the diet should be low-carbohydrate, not “hungry,” as you were prescribed.
> all diabetics around are complaining
> that he is not well tolerated
This is due to the illiteracy of the doctors and the patients themselves.
I was prescribed a Glyukofazh Long 750+ low-carbohydrate diet, due to impaired glucose tolerance. Glucose on an empty stomach 5.54, after two hours 7.8.
Insulin on an empty stomach 26,7. I am 34 years old, obesity is 1 degree, height is 161 cm, weight is 88 kg, body mass index is 33. In addition, headache and muscle pain are straining. The instructions indicate that they can increase. Lactic acid in the muscles. How to be? Three years ago, Siofor 500 was prescribed - abdominal pain, weakness, nausea, and vomiting began. After cancellation, I treated the stomach for a month. Now, in connection with this, Glyukofazh Long 750 was prescribed. The instructions say about lactate acidosis (nausea, vomiting, etc.), but how to understand between the so-called norm and the onset of this disease? Before starting treatment they write to check the level of lactate - how to do it?
I sit on a diet, the pill should have been taken as a month. I'm afraid to take this drug after a story with siofor. But the doctor insists, he says, I can not do without him. Tell me how to be? And is it possible to divide the Glyukofazh long into rugs and quarter pills, breaking its shell?
Thanks in advance for your reply, Elena.
> The instructions are written about lactate acidosis
This complication does not occur in practice.
> write to check the level of lactate
You can not do this if you have no liver or kidney disease.
> Tell me how to be?
1. Study the article about Siofor, start taking and gradually increase the dosage, as described there.
2. Pass blood tests for the thyroid gland. If there is a shortage of her hormones - treat, take pills, this is important.
3. It is advisable to do physical exercise with pleasure.
> And is it possible to divide the Glyukofazh long
> on rugs and quarter pills
I don’t know exactly, but most likely not. From one whole tablet Glyukofazh long you should not have a digestive upset. Take with food.
You have a progressive doctor. He translated from Siofor to Glyukofazh long, and he also prescribed a low-carbohydrate diet. Well done. Give him (or her) my respect. Few of these.
Hello. I am 35 years old, weight is 87 kg, height is 186 cm. Six months ago I completed treatment for hepatitis C, successfully. Now I am worried about insulin resistance. Glucose 5.6, insulin 13.8. My job is sedentary, but I pull up, squat, wring out. Now refused sugar in tea and coffee. Fat do not eat for a long time, do not drink, do not smoke. The belly and sides grow. Tell me, please, how to deal with this?
> Tell me, please, how to deal with it?
A low-carb diet can make your liver problems worse, so I’m not ready to advise anything about nutrition. Here you decide at your own risk.
> I pull up, squat, wring out
If I were you, I would add Qi-Bag to all this.
Hello, a child of 10 years old, height 146 cm, weight 43 kg. Full belly and sides, dancing, swimming pool 1 time per week. Stomach since childhood. The endocrinologist said that we have abdominal obesity, prescribed tests for insulin resistance and C-peptide. Analyzes received, but the reception by appointment only at the beginning of March. Our analyzes: glucose (fluoride) 4.1 mmol / l; insulin resistance index HOMA-IR 1.3; insulin 7.2 mcd / ml; C-peptide 430 pmol / l. I ask you to tell you if we normally have tests? Is there any reason to think that we have metabolic syndrome?
> Do we normally have tests?
Standards of analyzes are easy to find on the Internet, compare your results with them.
> Is there any reason to think that
> we have metabolic syndrome?
What to do:
1. Feed your baby on a low-carbohydrate diet, including taking snacks to school
2. Ideal for you to jog with him.
3. Arrange for not being bullied at school.
> reception by appointment only at the beginning of March
You can not walk. It is unlikely that there is something sensible advise. Do what I wrote.
Hello Sergey. Very interesting site. I have this question. What about alcohol? Vodka also does not contain carbohydrates. So drink or not drink? And if you drink, how much? I have read a lot of articles and comments on your site, but I haven’t found an answer to this question. And I am sure that many diabetics are interested in this, except for me. Thank you in advance.
> So drink or not drink?
> And if you drink, how much?
Read the article "Alcohol in diabetes," there are answers to your questions.
Good day! It torments such a question. If a person leads an active lifestyle, does a lot of sports, but at the same time he is addicted to fast carbohydrates - does he have a risk to earn insulin resistance? Or is this only relevant for those who eat a lot and move a little? on what scale do you need to eat carbohydrates, so that it becomes a real threat?
> a person leads an active lifestyle,
> a lot of sports, but at the same time
> fast carbs
Such comrades usually stop playing sports by the age of 40, and the diet does not change.
After that, insulin resistance and type 2 diabetes tell them: “Hi!”
Hello Sergey! I am 21 years old, height 171 cm, weight 53 kg. At about the age of 16, I was diagnosed with PCOS, as a rule, doctors prescribed hormones and said that nothing could be helped. Recently I was at the endocrinologist. Has passed analyzes:
Glucose fasting 4.00 mmol / l
Glucose one hour after the load (glucose was 100 g) 7.60 mmol / l
Glucose 2 hours after loading 5.60 mmol / l
Insulin on an empty stomach 5,39 mIU / l (2.60-11.10)
Insulin 2 hours after a load of 52.71 (2.60-27)
Also reduced the level of magnesium and calcium at the lower boundary.
For thyroid hormones:
TSH 5.34 (0.35-4.94)
T4 free 12.66 (9-19.05)
T3 free 4.47 (2.63-5.7) According to the results of a thyroid gland ultrasound - signs of autoimmune thyroiditis.
The doctor was diagnosed with hyperinsulinemia and autoimmune thyroiditis in the stage of subclinical hypothyroidism. Hence, as he said, all the problems with the menstrual cycle and the skin - always poured out the face very strongly. Treatment - diet, intake of magnesium, vitamin D, vitamin complex, zinc, eutirox, octolipen.
My questions are as follows:
1) If I have hyperinsulinemia, then I have insulin resistance?
2) why not overweight?
3) the process of inflammation in the thyroid gland began due to excess insulin? Or it could be the other way around: first, the inflammatory process in the thyroid gland began, which caused a violation in the production of insulin?
4) I understand that the main thing for me is the observance of a low-carbohydrate diet and exercise?
5) excess insulin can affect sex hormones? my level of total testosterone is normal, and 17-hydroxyprogesterone is off scale
> if I have hyperinsulinemia, then
> I have insulin resistance?
> why not overweight?
PCOS without overweight often happens in young women. Why dont know. You are not the only one. Treat yourself calmly.
> process of inflammation in the thyroid gland
> started due to excess insulin?
I do not know. Not sure that these problems are generally related.
> the main thing for me is respect
> low-carb diets
> and physical activity?
Yes. I also advise you to take zinc and vitamin A from acne. Find Atkins book "Bioadditives" and read how to do it. Please note that while taking vitamin A you cannot plan a pregnancy.
> excess insulin can
> affect sex hormones?
Yes. Probably, it will be difficult for you to get pregnant, despite the low-carbohydrate diet. When you are going to do this and there will not be a year, doctors will prescribe potent hormone pills and other activities.
Hello ! Thank you so much for the site. I learned a lot of information for myself when I was suddenly put on insulin resistance. I hope sports and low-carbohydrate nutrition to cope with it. Thank you once again for the theory, clearly and fully laid out on the shelves. I am 35 years old, height 160 cm, weight at this stage 99 kg. I was on testing at the sports club, where I signed up for more effective training. It's easier for me when I have a coach over me. On testing, after all measurements, a test load with cardio-sensors and a heart rate monitor, my base exchange was calculated to be 1400 kcal per day. The endocrinologist recommended sticking to 1200 kcal for more effective weight loss. How do you think, how many calories are optimal for me and most importantly, how to distribute them on BJU? I found the formula on one site: 50-60% for carbohydrates, 15% for fats and the rest - protein. Counted at the rate of 4 kcal - 1 gr. carbohydrate and 1 gr. proteins and 9 kcal - 1 gr. fat
BZHU 490/200/700 kcal = 122/23/175 gr. will help control and normalize insulin resistance or need a different ratio?
> how many calories are optimal for me
Do not count calories, eat approved foods by appetite, more often, do not overeat.
> BZHU 490/200/700 kcal = 122/23/175 gr
Do not be nonsense.
It is better to take blood tests for thyroid hormones. Change the endocrinologist. She should have referred you to these tests.
Hello! I sit on a low-carbohydrate diet, I also used metformin for weight loss for about 11 days at a dosage of 500 mg 3 times a day. After that, he broke down and ate everything that came to hand, from cakes to ice cream, for about a week. At the same time he drank metformin for the first three days to block carbohydrates. Please tell me how dangerous it is? Can I get diabetes from taking this drug? Thank…
> Please tell me
> how dangerous is it?
Here is a detailed article about metformin - I think it contains answers to questions that interest you.
Hello! I am 25 years old, height 170, weight 61. A week ago I was 65, but thanks to your diet, I quickly went down! Thanks you. I have a metabolic disorder, elevated insulin. Based on the test results, I look forward to seeing the doctor, but in the meantime I am on your diet, and miracles began to happen to me. Thanks a lot! I, however, have some questions about the diet, I will wait for your answers if you find time.
1) Cocoa and diabetic homemade chocolate are listed on your menu - can you tell me where can I find these recipes?
2) Everything is clear with yogurt, but what do you think about kefir / ryazhenka? They are at 4% fat - still can not?
3) And what do you think about other varieties of nuts besides hazelnuts and walnuts: cedar, for example, or cashews? I looked - the ratio of fats, proteins and carbohydrates is about the same, so I wonder if it is possible to alternate.
Thanks a lot in advance!
> Your menu shows cocoa.
> and diabetic homemade chocolate
You do not want to use diabetic chocolate, even homemade. You can only cocoa without sugar, sometimes a little.
> With yogurt everything is clear, and what are you
> thinking about kefir / ryazhenka?
Any dairy products inhibit weight loss, stimulate weight gain. They should not be consumed. Perhaps, except for hard cheese and yogurt in the form of jelly.
> about other varieties of nuts,
> except hazelnuts and walnuts:
> cedar, for example, or cashews?
Cashews - can not, cedar - you can, if they are available to you.
Good day! I am 34 years old, height 188 cm, weight 90 kg. The sugar level was 6.4 on an empty stomach. I started to eat according to your method - the weight dropped from 97 to 90 kg. The level of sugar decreased by one in a few days. However, twice in the morning I woke up in the pre-fainting state (hypoglycemia), sugar was 2, another time it was 0.8. Cured by glucose tablets. To avoid this, began to eat carbohydrates at night. What do you advise?
Dine on protein foods, not carbohydrates. Calculate dinner time so as to go to bed not hungry, but not with a full stomach.
I try to have dinner no later than 18.30-19.00. After that, I have breakfast early - sometimes at 5-6 in the morning. Then I can still sleep. In my opinion, this is the best mode for our problems with you.
sugar was 2, another time 0.8
With such sugar, you would fall into a coma, you could not measure it yourself and take glucose tablets.
The sugar level was 6.4 on an empty stomach.
It may already be type 2 diabetes, not just insulin resistance. You need to have an accurate home blood glucose meter and check your sugar more often, including after meals.
I have a question about my daughter. Her weight is 105 kg, height 155 cm, age 19 years. Suffering from childhood obesity. Sugar fasting 4.6. Already 19 days sitting on a low-carbohydrate diet, but weight does not decrease. As far as I understand, she has endocrine type of obesity (arms, legs are thick). We signed up for a doctor to get tested, and we would like to know which tests to focus on. At the age of 13, the endocrinologist prescribed glucofaz, but after that we were not observed by the doctor. Tell me, please, what to do?
which analyzes to focus on
On blood tests for thyroid hormones - T3 is free and T4 is free, not just TSH.
With high probability, hypothyroidism is detected, which is the main cause of your daughter's health problems.
Moreover, hypothyroidism is the best option. All other possible hormonal disorders are worse.
It is necessary to learn English and read materials on it, how to normalize the work of the thyroid gland. In particular, the book "Why Do I Still Have Thyroid Symptoms?". Unfortunately, I don’t have it in Russian, and I don’t plan to translate yet. And domestic endocrinologists treat the thyroid gland with about the same success as diabetes.
Hello. Sorry for not a very smart question.
Please tell me if the analysis for the NOMA index may be wrong?
I know little about myself, I just began to be examined.
Mom ate sweets without measure, did not feel how much. Grandma type 2 diabetes and blood clots. As a child I was in the hospital after a couple of boxes of chocolates, since then with pancreatitis. Well, it happened, a mosquito will bite in the summer, comb it - by the winter it will heal. Children's card is left. Tests on sugar with a load in childhood I remember.
I have periods when I do not control the amount of sweet, I gain weight. Then the pancreas or gall is aggravated - and I'm on a diet, I lose a little weight, I don't want sweets.
The endocrinologist prescribed NOMA when he was eating, and while I was going to do the analysis, high pressure happened the third time in my life, I did not eat for a couple of days, there was a bile attack, I do not want sweets, and for the second time in my life I got thrombophlebitis. Has handed over NOMA - it is normal (glucose 5.86, insulin 8.99, NOMA 2.34)
Should I retake it when I again have a period of strong need for sweets? Or does it matter if I ate cake or oatmeal on water a day before the analysis?
Hello. I am 45, weight 120, height 180, insulin on an empty stomach 23, sugar curve with a load showed the absence of diabetes. The doctor prescribed a glucofage long and diet, observed everything, the weight began to decrease, but insulin showed 48 after repeated analysis! Now the state of health is bad: there is no strength, in the evening cotton legs, it is difficult even to pronounce the words. I do not know whether to associate this condition with insulin or not. Tell me what tests to pass? Thank you in advance.
Hello, I recently donated blood for lipid profile and triglecerides.
Atherogenic Index - 5.8
Triglycerides 2.85 mmol / l 0.56 - 3.01 mmol / l
Cholesterol 5.00 mmol / l 3.57 - 6.58 mmol / l
Cholesterol-HDL 0.74 mmol / l 0.72 - 1.63 mmol / l
Cholesterol-LDL (according to Friedwald) 2.96 mmol / l 2.02 - 4.79 mmol / l
How can you increase good cholesterol and do you need to do this in principle?
It is also worth clarifying that I gave these tests during hepatitis C antiviral therapy.
Is it possible to normalize the balance of cholesterol after the end of therapy?
I am 26 years old. I’ve recovered sharply at 21 years old at 20 kg. I’m doing sports all my life. Snowboarding. Studied at a tennis school. I’m going to the gym, swimming pool, not a sedentary job. An active lifestyle is present in everything. About 20 years later, problems started with the menstrual cycle, the blood went on for three months. As a result, ovarian dysfunction was diagnosed. I live on the whole life correctly, I don’t eat fat, flour and sweets since childhood. But the weight does not go away. The gynecologist advised to donate blood for insulin. city of doctors. nobody can really say anything I passed a bunch of tests, all the organs are in order. I drink metformin to a weight of 5 kg and after some time they come back. Now the doctor suggested eating 6 times a day for 1,400 kcl of which 60 are proteins, 20 carbohydrates, 20 fats and continue to drink metformin . Tell me if this helps? I found out about the new medicine galvus-med. How should I use it?
I understand that getting pregnant with high isulin is very difficult. And we want children with it. Help me please.
Hello! I have a few questions about the diet:
1. Is it possible to use sunflower oil, for example, as a salad dressing? After all, the main menu during the diet is green vegetables, and they are tastier in salads.
2. Regarding meat, poultry and fish. How to cook them properly during a low-carb diet? Cook, pickle, fry, bake, smoke (smoked fish)?
3. Regarding mayonnaise and garlic. I realized that milk, kefir is impossible, cream is possible, and mayonnaise? Again, as a salad dressing, for example. Onions can be green, and the usual - quite a bit and raw, and garlic?
4. Melted cheese. Can I eat them? About soup and borscht, you can't eat them, right? There is necessarily zazharka, and beets, and potatoes. What can be replaced? Slap empty chicken or meat broth?
5. White bread is impossible. And black?
Hello. I am 38 years old, weight 99 kg, height 178 cm, thyroid and hormones are normal, kidneys and adrenal glands are normal, hypertension of 2 degrees, I take 2.5 concor every morning, 3 times a day for Magne b6 1 tablet. Pressure in the evenings 115-110 / 70-85 in the afternoon 130-135 / 80-90
the brain is also normal. Passing the head of the head, ecg and ultrasound of the heart. Hypertrophy of the left ventricle septum 3mm. A slight liver obesity, quit drinking and smoking 3 months ago. Glucose on an empty stomach in the morning 5,972 in the afternoon 4-5. Insulin in the morning on an empty stomach 12.66, creatine 0.9, glycated hemoglobin 5.56. I have and hyperventilation syndrome. For the last 3 months I have been suffering from symptoms of hypoglycemia, although 4.Confets and sweetness do not help with the manifestation of symptoms of blood glucose. only white bread helps and for this syndrome in 3 months I gained 5 kg and right now 99 kg. Which doctor should I go to, where should I go? help advice please.
Hello. I am 38 years old, weight 99 kg, height 178 cm, thyroid and hormones are normal, kidneys and adrenal glands are normal, hypertension of 2 degrees, I take 2.5 concor every morning, 3 times a day for Magne b6 1 tablet. Pressure in the evenings 115-110 / 70-85 in the afternoon 130-135 / 80-90 the brain is also normal. I went through head, ecg and ultrasound of the heart. Left ventricular septum hypertrophy 3mm. A slight liver obesity, stopped drinking and smoking 3 months ago. 4-5.Insulin in the morning on an empty stomach 12.66, creatine 0.9, glycated hemoglobin 5.56. I have all over and hyperventilation syndrome. For the last 3 months I have been tormented are the symptoms of hypoglycemia, though the manifestation of symptoms of glucose in the blood 4.konfety and sweetness are not helping. only white bread helps and for this syndrome in 3 months I gained 5 kg and right now 99 kg. Which doctor should I go to, where should I go? help advice please.
Thank. So lucidly, clearly and logically covers all aspects and problems that insulin resistance captures, and the reasons are explained. The author feels systemic thinking! I have not read anything like it yet. Excellent. Just why are your colleagues in such ignorance? They attend various refresher courses, and in the medical institute they learn something. You would not be able to take the initiative and “impose” yourself with your knowledge on such training courses for general practitioners and doctors of various practices (for example, gynecologists with polycystic ovaries). They should also learn how this problem works and how to deal with it. They should more often help people deal with this problem. Thanks again.
Good day! I am 30 years old. Six months ago, they diagnosed MODI diabetes. Siofor 850 said so far, but the transition to insulin will be quick. Symptoms asked by the endocrinologist began long before the officially diagnosed. For 6-7 years. Who knew how it would end. I was treated separately by the kidneys, a separate liver and all that. Sugar on an empty stomach was 7.2 with a load of 16. Insulin is twice as high as the extreme values of the norm. Glycated hemoglobin 7.3. How to find your site immediately went on a low carbohydrate diet. Weight decreased, complexion improves, sugar maximum 5.7 good mood))). I have two questions for you: I have flat feet and valgus deformities of the thumbs. It is very hard to walk and stand, not to run. I wanted to have an operation, but now I'm afraid. Tell me if I can do the operation on the foot? Is it fraught with complications? And the second question: MODI diabetes - as the doctor told me mutation of genes. And in the end, they still transfer me to insulin. But a low carbohydrate diet helps me a lot. As if I have type 2 diabetes, it may still be possible not to switch to insulin?
Good day! I have big problems in endocrinology, Height 175, weight 90. I passed the analyzes of TSH-1, sugar-5, insulin -0.40 is very high! The doctor prescribed me a siofor-850. what to do?
Hi, I am 31. Growth 171 weight 113. Glucose 9.98, Insulin 43.39 Nome Index 19.25 Is the test of diabetes 8.09%?
Hello, during pregnancy passed the test for glucose tolerance. Result on an empty stomach 4, after 2 hours - 10.
diagnosed ntg. Now after birth, half a year has passed. Today passed tests. Sugar on an empty stomach 4, as always. But glycated hemoglobin - 8.6. I'm shocked. Is it diabetes? Gave the direction for the analysis of glucose tolerance ...
Hello, today donated blood for glucose + insulin. Scared terribly: glucose 6.36; insulin 31.2. What is it? What to do? Tell me. I am 43 years old, weight 100 kg.
Oh, in the previous comment, I incorrectly indicated fasting glucose!
Glucose fasting - 5,06
Glycated hemoglobin - 5.7%
The test with the load and glucose after eating - did not pass.
Bad cholesterol is normal.
Prediabetes? And is he a risk, or a guaranteed start?
Please, tell me ... and then the doctors twist my finger at my temple, they say that everything is fine with me. I really hope that I just hysteria ...
Hello. I do not have a high degree of insulin resistance and I have neither excess weight nor high sugar. But during hormonal rearrangements, and there are three of them in the life of a woman, everything is greatly aggravated. I am 47 and the fall of female hormones has greatly aggravated the situation. The gut behaves very badly. Constant inflammation. Many symptoms of diabetes. I stopped eating all the flour easily, and I try to eat less sugar. Chocolate do not eat in general. I certainly felt a lot easier. However, the lack of carbohydrates led to an increased load on the kidneys and the urine began to smell like acetone. In addition, in quite innocuous products a lot of hidden sugar and the last, I can not refuse from the sweet snack at all. To solve my problems, I started drinking artichoke infusion with ice cream, for example. It helps a lot to regulate insulin, but this is a herbal solution and not always sufficient. I want to feel even better. I have a question. Is it possible to use metformin by little in my situation during those moments when you eat something sweet? Or is it too serious medicine? I heard that the one who starts to use it regularly, quickly switches to insulin. What do you recommend in my situation?
Hello! Tell me, please, what the results of my blood test mean: I am 31 years old, height 158 cm, weight 45 kg. I was diagnosed with PCOS, the ovaries are enlarged, on the left side it feels physically strong hair loss, subcutaneous acne on the forehead, the absence of menstruation without taking progesterone.
LH = 30.19 mIU / ml,
Anti-puller hormone = 21 ++ ng / ml,
Progesterone 1.8 nmol / l,
These hormones seem normal:
FSH = 7mu / ml
Prolactin = 13.3 ng / ml
Testosterone = 2.61 nmol / l,
DHA-S = 273 µg / dl,
Estradiol = 218 nmol / L.
Blood test for glucose and insulin:
On an empty stomach: glucose 4.7 mmol / l, insulin
please tell me, yy 6.2, sugar on tooshchak 3.9. I follow a low-carb diet. Do I need to be treated? doctor from the clinic speaks of the honeymoon.
Hello. I am 51 years old. Height 170, weight 79. (gained over the last two or three years. I sin on hormonal adjustment). I have occasionally experienced bouts of hypogikecaemia (and this is hereditary, it happens in my mother and in my 26-year-old daughter). Diabetes in the family did not put anyone. Several times during the attack, I measured sugar with a glucometer. I have never caught a figure below 3.8. More often 4,2. But at this moment I feel very bad. Hands tremble, in the eyes of dark sweat and all the other charms. After eating lets go. The most interesting thing is that sometimes with the same values I feel fine. And recently there was such a strong attack that barely crawled out of it. To measure sugar at that moment was not possible. But since then I carry a meter with me. And then the news. The second day in a row, two hours after coffee with cookies, sugar is about 10 !. Then decreases. An empty stomach yesterday was 5.4. A couple of years ago, she gave some tests and turned to an endocrinologist about these bouts of hypoglycemia. Glucose-4.99; glycosylated hemoglobin-4.90; insulin-4.8. The doctor said that this is an eating disorder and a sedentary lifestyle (sedentary lifestyle, steering wheel, etc.). Tell me what it could be? I am anxious and worried. Thank)))
I visited the site very in time, since I suffered the same problem. Until today, she absolutely knew nothing about diabetes, or about thyroid, cholesterol, etc. Once in the hospital with a spinal column, she passed a blood test and found elevated sugar in it. Decided to conduct a more thorough examination:
Triglycerides -1.75 at a rate of 0.41-2.96
total cholesterol - 6.53 at a rate of 3.08-6.77
cholesterol HDL - 1.66 under the norm> 1.50
LDL cholesterol - 4.52 when normal
I am 49 years old. Abdominal obesity 2, hypertension. Sugar, cholesterol, hormones in the normal range. Index NOMA 4.5. Began to follow a low-carb diet. It is very difficult - I want to eat all the time. Is it possible to add Siofor? If so, in what doses?
Hello. Mothers have type 2 diabetes for 10 years. Now she is in the hospital after the surgery. She is given insulin shots. It does not help. Sugar does not fall below 20. What should I do?
Very interesting site, a lot of important and necessary information. As always, try only on yourself and yourself.
It torments such a question. How to eat when working in shifts. Eat and what at night or just drink water, and eat in the morning before going to bed, coming from work? When to do the last meal if you come home from work in the second hour of the night? If you can not cereal for breakfast, then what should it be? Cottage cheese and coffee with sandwiches is also not desirable, but then what?
Hello. 52 years old, extra weight 30 kg. The other day I learned that I have very much increased insulin (383 pmol / l), at a rate of up to 180. Sugar is 4.5, it is always normal. Today, an endocrinologist told me to take Metformin 1.0, 0.5 tablets 2 times a day to reduce insulin. Only in the annotation to the drug, I read that it lowers sugar. I will be able to visit the doctor at least in a few days, but I want to know now. Maybe the doctor was wrong or something confused? Tell me, do I need this medication and will it help reduce insulin? thanks in advance for the answer and for the article
Could you tell me please, I have CD, 2 types, Tresiba insulin for 40 units and for the year recovered 13 kg of pill took repaglinide 1 t 3 r / d both in the morning and in the evening Metformin 1000, after I recovered the doctor sent for surrender C he showed a peptide of 1.49 at a rate of 0.79-4.19, but the doctor quit and now I don’t know what to do. I’m 62 years old with diabetes for 30 years hereditary diabetes mellitus. Tell me please, can I have pills stronger than I take ? Help!
Good afternoon, question. I am 31 years old, height 155, weight is now 73 kg. Weight gained after giving birth, in 2 weeks gained 10 kg. The homa index is elevated, the doctor prescribes Siofor and a diet. I do not like sweet, rarely eat flour, mostly black bread. I have not eaten flour for the last month, I have completely eliminated potatoes, I have also excluded sugar. I didn’t think that everything would leave right away, but I don’t notice any changes, except for the swelling. True with physical activity rather weak. I would like to know when to wait for some results? Can you tell me something more detailed on the menu, followed the link in the text that I did not find, I can not figure it out. I also want to give up animal food, but I’m not sure that I’ll be right. And how about fatty foods, is it necessary to limit fats?
Hello. I am 40 years old, 146 weight 49 kg, a year ago I was diagnosed with type 2 diabetes, I was prescribed siofor 500, I stopped taking it for a month, I had sugar for 4.6-5.7, glycated hemoglobin was 5.6 but after eating sugar rises to 9, I do not feel those symptoms of diabetes, is it possible to speak about diabetes or is it prediabetes?
Hello, I am 37 years old, the weight of 76kg recovered sharply by 14 kg, I passed the tests ttg 36, t4 8.48 and. The analysis of glucose for toeschak 5.4, after an hour 6.7 and after 2 hours 4.9. I drink eutirox 50 dropped ttg to 2.5 and sharply affected tgg on this dose after stress rose to 8.4. Hemoglobin 107 with nomra 117 - 130. Frequent changes of mood, apathy.
Tell me please, do I have pi such insulin? . I can not lose weight, I go a lot, ruled out sweets and bread. Please, please answer me the question if I drink everything correctly? And do I have insulin? The doctor prescribed to drink glucofage long, but I have not yet drunk. I'd love to hear your opinion, I really want to lose weight and be healthy .. thanks a lot.
hello, lately strong thirst began to drink, I drink more than 5 liters of water, so I often run to the toilet, even waking up at night from it. In addition, bruises / abrasions do not heal for months, even minor ones, and I can’t throw off weight (height 172, weight 85), despite being engaged in the gym, suspected diabetes, (besides my grandmother had type 2 diabetes ). Passed tests for glucose (the result of 4.4 mmol / l) and glycated hemoglobin (the result of 4.6%) everything turns out to be normal. Tell me, please, can it be insulin resistance and what can be done to precisely exclude diabetes?
Hello. I am 30 years old. Height 169, weight 80 kg. The level of sugar on an empty stomach is 4, the hormone is insulin 17. The endocrinologist appointed Metphogamma to drink 500 first in a month to increase it to 1000. Another doctor prescribed Turboslim to drink 2 tabs in the morning with food. When I increase the dose of metfoham, I have low pressure in the morning and headache. Weight is not particularly reduced. Thyroid hormones are fine. How to reduce insulin in the blood and to not fall indicators of sugar?
Tell me - can buckwheat be included in the list of acceptable products? And if so, in what form? thanks in advance
Hello Sergey! I am 26 years old, height 158 cm, weight 69 kg. At about the age of 17, I was diagnosed with PCOS, as a rule, doctors prescribed hormones and said that nothing could be helped. Results of recent analyzes:
Glucose on an empty stomach (plasma) 4.7 mmol / l
Glucose 2 hours after loading (plasma) 9.2 mmol / l
Fasting Insulin 7.5 mIU / L (2.7-10.4)
The index of insulin resistance NOMA 1,6 (
Hello! I am almost 66 years old. Height 163 cm, weight at the moment 101 kg. A year and a half ago I began to dramatically gain weight (from 80 kg). The reason - a knee injury in the winter in the ice - about 2.5 years ago. There was bed rest, limiting the load on the foot. Before the injury weighed about 80 kg, rode a bicycle, twisted an exercise bike, walked with Scandinavian sticks for 7 km at a speed of 4 km / h. In winter there were skis. After the injury, when crawled out into the street, of course, the speed of movement was low. Bicycle and exercise bike had to be deleted. Now restored the speed of the Scandinavian walk. Winter already and skiing.
I don’t take sugar and sweet at all for 45 years. I practically don’t eat bread and potatoes. Food consumption - no more than 1000 kcal.
And in March of this year, sugar was found on an empty stomach 7, and glycated hemoglobin was up to 7.8. They registered siofor 1000. With enthusiasm, she began to take it. About diarrhea on the background of its reception - I will keep silent. About nausea and aversion to food - too. Found that with my normal pressure (125/85) when walking with sticks, the pressure drops sharply to 100/60. Home already barely crawl. There is no question of any physical activity. The level of sugar on an empty stomach even began to rise to 8.5. The doctor suggested replacing siofor with Formetin 850. She switched to Formetin - the same effect. Moved to Kombogliz prolong - the same results. I can say that every time I see that sugar is higher than what was originally discovered, I start to panic. The only result that was slightly pleased was the reduction in weight to 101 kg.
Help, please understand!
Good day. Recently I went to the doctor with complaints of pain in the right hypochondrium, as well as frequent fatigue, drowsiness and apathy. Prescribed an abdominal ultrasound and tests for parasites. The preliminary diagnosis of chronic pancreatitis.
The ultrasound results showed increased echogenicity and moderate heterogeneity of the structure of the pancreatic parenchyma. The same blood test for sugar nataschak 4.1. She herself donated blood to C peptide. The result was 882pm.
Before the ultrasound was going to go on a low-carb diet from your site, because I assumed that I had high insulin, now I'm afraid to do it.
With my height 164cm weight 85kg. With diets I constantly break down and constant fatigue has already tortured me, and I am only 28 years old ((((
Tell me what to do?
Hello! I am 60 years old, height 167, weight a year ago was 92 kg. After the tests, it turned out that the sugar level was 6.9 ... after two months when re-taking it was -6.5. During this time, weight decreased by 4 kg. For three months I went Nordic walking, dropped 7 kg. I stopped walking with sticks ... I got into the center for weight loss using hardware methods plus a diet (As it turned out, after reading your information, the useless and even harmful for me, the so-called nutritionist did not even look at my analyzes ...), It is clear that the problem is already overdue ... Thanks for nutrition information and recommendations; Nordic walking will be resumed in the coming days. I work 3 days per day, but only in spring and summer I cannot run, a hernia of the lumbar spine operated 12 years ago and a new, 5.6 mm, cervical and thoracic osteochondrosis and disc protrusion formed at the same place.
Hello! Thank you for the article! need advice! I am 43 years old, height 164, weight 97 kg. The results of analyzes of sugar on an empty stomach and insulin fit into the norm, but at the same time the insulin resistance index is exceeded by 2 times - 4.77. Hormones are all normal, except for prolactin, it is elevated 1415-3200 mIU / l. An MRI of the pituitary did not reveal any lesions, but there are diseases of the gastrointestinal tract - duodenal ulcer, cholecystitis, pancreatitis, and fatty hepatosis. The pressure is normal, total cholesterol is increased 6.75 mmol / l, HDL and LDL are normal, triglycerides are 3.62. An endocrinologist offers nothing but a balanced diet. Such a diet does not help me for 2 years in combination with physical exertion. Tell me, is it possible to bring everything back to normal, how to choose a treatment regimen?
Good evening! Accidentally found you in a search engine. Problems with her husband. 43 years old, height 189, weight was 124 kg. Went to a doctor about the treatment of thrush. The doctor prescribed the treatment, sent him to donate blood for sugar. The result killed us. 10.8 ... according to your recommendations, you switched to a low-water diet. Given that our doctor (endocrinologist) was very against it. The stories about the table number 9, as the most necessary we were not convinced. The only thing they started to take is 750 Glucluf for the night.
The result ... for the month dropped 10 kg. Sugar in the morning on Toshchak 5.5..5.8. During the day after a meal is not higher than 6.0. Moving further to the planned healthy life (weight loss to normal 89-90 kg and blood sugar 4.6.
Thank you very much for your work.
My husband is very pleased with the results. When communicating with other patients with diabetes, advises your site!
Hello. I am 42 years old, at 25 years old, after pregnancy, the gallbladder with a stone in the duct was removed. After this operation began gaining weight, craving for sweets. With the growth of 176cm, the weight was always 60-65 kg. Now 87-88 (((. Liver problems started. Fatty hepatosis. Chr. Pancreatitis. I drink glukofazh long 750 1 t.n. night, ursosan 4 caps a day. Sugar on an empty stomach 6-6.7. I am a vegetarian, sugar, I do not eat white flour either. Weight does not go away. Sport 2 times a week for an hour. What am I doing wrong?
Weight 127, height 170, woman, not ry., Abortions were not, 5 times a week gym, calorie control 1300kkal / day, split meals. Analyzes: the level of insulin resistance is 12.96 (the norm is 0-2.27), the protein according to the general urine analysis is 0.29 (the norm is 0-0.14), total cholesterol is 6'67 (the norm is 0.0-5.2), glucose 5.63 (norm4.1-5.9), glycated Hb 5.6 (norm 4.0-6.2), insulin 51.8 (norm 2-29.1), mtg 4.52 (norm 0, 4-4.0), testosterone 2.95 (normal 0.9-2.5), T4 cp 0.838 (norms 0.89-1.76). I can not lose weight, the weight goes very slowly. Total minus 5 kg for 1.5 months of diet and sports loads. Weakness, drowsiness. Why? What could it be? What is the reason?
Hello . I have insulin resistance. My weight is 80 with height 162, I am 19 years old. I am very afraid to drink glucofaz. I have a couple of questions about this. All year I traveled many doctors and finally got to the bottom of my body. The fact is that initially I turned to the gynecologist about intermenstrual discharge, I was sent to the surrender of male and female hormones and also to make an ultrasound to exclude pathology. I did everything, in the end everything was perfect, but they continued to torment me and continue intermenstrual discharge when I was undergoing ultrasound, the doctor advised me also to take insulin, but already 2 hours after eating. Well, after all the women's studies, I went to pass on the insulin as they wrote to me. And as a result, I was shocked by 194, to put it mildly, ofigel from the result and the doctor told me that he should come back to normal after 2 hours, e, from 3-29. I didn’t believe I sat down on a low-carbohydrate diet, after 2 weeks I went on an empty stomach, he was 19 out of 29, and then came in 1 hour and 45 minutes later, and after a few days, the result was that after eating 50 (again, interval from 3-29). I again went to the doctor she said that it was still not a little and said drink 3 months
14 days - 1 tablet per day
Further 2 tablets per day after meals.
also recommended a remedy for edemas (I sometimes have them) such as verpieron
and chimes (1 month)
I wonder if it is possible to mix these drugs?
And what drugs can not be used with metformin (in my case, glucofaz 500) I have an IRR, so I often on sedatives and sometimes on tranquilizers.
And the question is, I have such a very mild stomach; he doesn’t take many pills very much, will not glucofage kill my stomach?
And also if insulin goes back to normal after eating, then my intermenstrual discharge will stop?
Because the doctor told me that this is possible from elevated insulin because it primarily hits the ovaries. I’ve been reading a lot about ovulatory syndrome on the Internet, but before that I didn’t have that and the extra days in the middle of the cycle torment me.
I am also tormented by copious periods, it all started from the age of 17 as I began to gain weight because of the high cravings for sweets. I can't live without him.
Is it because of my nutrition that I got such insulin? Something like this scheme, you eat a lot of carbohydrates, get fat, and then the result is increased insulin?
By the way, I lost weight because of the low-carbohydrate diet, but soon when I quit I typed it again. Is there no way for me without metformin?
I'm only 19, I'm afraid to drink such a serious drug.
Hello. 34 years old. I recently switched to low-carbohydrate nutrition, and my blood pressure immediately rose, up to 130/90, usually 110/70 in life. Hyper-irritability, difficult to fall asleep, noise in the temples. While the general condition has improved dramatically - a lot of strength, no fatigue after eating (which was chronically), although now with a couple of tablespoons of honey or an apple, all the symptoms return for a while, I checked. Height, weight 168/62, physique lean, but belly fat was formed in life when overeating immediately. Insulin resistance is anyway old. And hypoglycemia is the same. In the first week there were pits when I felt it especially, I was eating glucose. Now, (three weeks have passed) this has decreased, it happens except in the early morning. Began to drink zinc and chrome. I drink magnesium and taurine (drank 500) now became 100mg each. In general, I feel a significant improvement, but the pressure is very disturbing. What could be the reason? Isolation of insulin according to the normal for the body norm (that is, not yet rebuilt) and glucose for him there? Or maybe from overeating, but does not seem to, do not eat to a full stomach.
I am 50 years old. I weigh 120 kg long ago. Cheerful, active.
I go in for sports for 20 years (especially aqua aerobics) for a lot of hours a week. 20 years do not eat pork, mayonnaise, white bread .. very rarely sausages and all harmful. Always wondered why not losing weight. but it didn’t hurt me to live like that .. earlier
Nevertheless, the weight is not reduced .. I can not starve
Once I tried to lose weight, I went in for sports for 14 hours a week, plus a fasting day and did not eat in the evening.
At the cost of such efforts, the hardest - she lost 20 kg, then quickly gained 40 ..
So: insulin resistance and cholesterol are bad tests ... everything else is normal. but this, as I understand it, for now ... the genes are good.
But! What else can you do? You advise everyone to sport, but I have plenty of it .. so there is no way out? wait for diabetes and so on? at the Institute of Nutrition said so ..
My daughter has polycystic ovary.
Against this background, insulin resistance develops.
Do you need a low-carb diet?
The sites recommend 5 times low-calorie meals up to 1800 cal. And doctors also recommend.
All recommendations are working. The sugar actually decreases (in my case, from 10-13 in the morning on an empty stomach to 5.2-6.2)
Initially, it is difficult to abandon sugar, sweet and potatoes, but after 1.5-2 months the body adapts and nothing like that is already felt.
A nice bonus - minus 15 kg for 3 months. and wellness.
Exercise - repeatedly enhances the result.
Thanks to the authors and administrators of the site.
Everything is simple and understandable, logical and most importantly, it works, what other arguments are needed?
For those who are looking for a solution to their problem, this technique is a solution, but for those who expect a super tablet to jam a cake, we wish good luck, strength and health. They need it.
Very useful site! Thank!
I read about the pre-dawn increase in blood glucose, which was confirmed by experience. In the middle of the day on an empty stomach (8 hours) the glucose level is lower than in the morning after sleep.
What can you say about this ?.
good day. accidentally went to your site. I wondered why I didn’t lose weight 158 weight 80kg lasts 5 years. I read the article and realized that I have insulin resistance, transferred hepatitis B to 25 years. There were problems with gynecology, last year there was an attack of pain in the waist and the doctors didn’t determine anything because the analyses were fine except for amylase and glucose increase ... I think that this is an attack of the pancreas. I'm a terrible sweet tooth: fruit. baking. Moving on a low-carbohydrate diet! I am 61 years old I go to work and from work on foot 30 minutes in one direction. I want to lose weight and become more active. I will send my reports. You are doing a GOOD business, a low bow to you!
I have no glucose resistance. In the morning sugar 5.0 - 5.3. After eating, if any carbohydrate is ingested - 6.6 - 6.9.
I follow a three month low-carbohydrate diet. When she started dieting, cholesterol was 7.5. Donated blood to cholesterol after 2 months of the diet - cholesterol rose to 8.45 !! Just a disaster. I thought that, as they wrote cholesterol will decrease. Strictly keep everything. After the sport, the glucometer shows sugar - 6.9. In general, I do not understand anything. She stopped doing sports, because this kind of sugar after sport with intolerance is very strange. Engaged in the morning. The indicator of the blood glucose meter after sleep is 5.0.
Can anyone explain what is happening?
I am 25 years old, weight 109 kg, height 177. Yesterday I received the answers of analyzes, insulin rolls over, sugar is normal. Insulin resistance. Prescribed metformin. I started to lose weight before that and already dropped 4.6 kg. Do I need to take metformin if I'm already on a diet? If I start taking metformin, will the body get used to it and after that I will not be able to do without it? Very scary.
Hello, already a month on a low-carb diet, even on a ketodiet, clean carbohydrates per day 30-40 grams, proteins 80-100 grams, fats 130-140 grams, fasting sugar 9-12, glucofage long 500 in the morning, but the weight is worth, sugar costs . Height 168, weight 105 kg, sedentary lifestyle, I understand the weight is, but why sugar. Please explain what I am doing wrong. Thank.
Good day! I would very much like to understand the concept of "CARO Index". Namely, I can not understand what the norm of this indicator. Half of the articles on the Internet say that the norm of this index is more than 0.33. In the other half of the articles, with the accuracy of "the other way around" information is provided that the rate is up to 0.33. Where is the truth? If one knew on what basis such an analysis was developed and what its physiological meaning would be, it would become clearer.
Good day. I am 30, I have some signs of type 2 diabetes: frequent urination (all my life), weight 86 kg. with height 155, abdominal obesity (all life was, even when the weight was within) and upper arms (appeared in the last 3 years), increased pressure (appeared about a year ago). But my sugar (fasting) is normal - 4.85 out of 5.89 permissible, while insulin 44.4 out of 24.9 permissible (increased by 20 units per year). HbA1c, cholesterol is also normal, slightly increased C-peptide. The endocrinologist kicks on the congenital pathology of the adrenal glands and does not want to look for the cause, but, I believe, it would have been realized much earlier (I gained weight after 26 years sharply from 58 to 86 kg.). Normally, the liver, pancreas, adrenal glands, pituitary, 2 times remade ultrasound and MRI - all within the normal range, no cysts, tumors, etc. My result from sports and diet - minus 6 kg. for 8 months, very slowly, now I want to try your recommendations. Siofor I eat 1000 a day also on the recommendation of an endocrinologist, but he does not help me - appetite is terrible, once every 2 hours it feels as if I haven’t eaten a day. Can you tell me where else to look for the cause of such a huge level of insulin in the blood? Is diabetes still or not? As you correctly described above, the doctors on us are damned, only the third endocrinologist guessed me to send insulin in general, I’d get desperate to look for a specialist, I want to figure it out myself and figure out where to dig further
A couple of years ago, you pushed me to a carbohydrate-free diet. Observing it, sugar, when measured several times a day, before and after meals was normal. And no pills, those that the doctor prescribed for me (diabeton, before reading your site saw them for 2.5 years). I lost 13 kg, I felt great. but the moment came when the zucchini, cabbage, cucumbers, and, of course, meat, cheese, were bored as hell. She began to eat bread from time to time, and she didn’t refuse watermelons with melons :). At the same time saw Metformin; yes, she suffered from side effects, and therefore she saw him only if she did not have to go out of the house anywhere :). Weight is growing, recovered by 6 kg. Drowsiness after taking carbohydrates appeared again, I know that you cannot use them, but I realize this only after eating :). Physical activity? Of course, decreased with the end of the summer season :). I want to thank you! The site, of course, has now become difficult for perception, and advertising is annoying, but the main message is understandable, at least for me. Thanks again for the enlightenment and motivation!
Good day. Two years ago, I dramatically gained weight: from 65 kg to 96 kg with an increase of 159 cm. My weight began to increase dramatically when I was in the hospital. She got to the hospital with sinusitis, lay for 10 days, all this time they were pricked by PRINISONE. After discharge, I began to swell just before my eyes. After half a year she turned to an endocrinologist (she passed all the necessary tests). The doctor said that according to the test results, I had elevated cholesterol levels. But she said that there was nothing wrong with that, she did not give any particular recommendations, except to exclude mayonnaise, white bread, fried potatoes. After a couple of months I had to go to another doctor, because my general physical condition began to deteriorate noticeably, the following symptoms appeared:
- continuous weight gain (and fat deposits were observed in the abdomen and neck)
- severe headaches
- pressure increase
- heart palpitations (in normal calm state up to 95 beats, while moving - up to 100-105 beats)
- chest pain, severe shortness of breath
- increased sweating
- vision has noticeably deteriorated
- fatigue, drowsiness, fatigue, irritability, nervous breakdowns
- severe edema of the body (especially in the legs).
Re-passed all tests. The doctor said that I have insulin resistance. Glyukofazh appointed for 3 months. In the diet to exclude all fatty, sweet. The first time was severe nausea, headaches and dizziness. Weight began to decline slightly. After the termination of the Glyukofazh course, the weight stopped. I independently began to walk for 2 hours at a brisk pace in the evenings, since I can not run, during the run pains in the heart and shortness of breath begin. In total, I dropped 14 kg. Now my weight is 82 kg. I don’t observe any improvements with health, the symptoms remain the same, the weight has stopped .. and in the last two weeks I started to increase. What can you advise me? What should I do? I understand that first of all I need the help of a doctor, but I don’t even know who to turn to, I went around a lot of doctors, and everyone has his own diagnosis, where to find a real experienced doctor who can help me ... ((((
Hello. Tell me there is no diabetes but there is insulin resistance. It is somehow treated. In the sense that I exercise bodybuilding and periodically I sit on the mass, without it, no matter how, on the mass I raise the calories and the amount of carbohydrates, respectively. Tell me how to be anything to sit on low carbohydrate?