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Common information

olanzapine hydrochloride 5 mg

Olanzapine is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.

Controlled Clinical Trials of Oral Olanzapine as Adjunct to Lithium or Valproate.

As assessed by measured values from clinical trials in the Olanzapine Integrated Database.

Appropriate clinical monitoring is advisable in accordance with utilised antipsychotic guidelines, e. The following table enumerates the percentage of patients with treatment-emergent extrapyramidal symptoms as assessed by categorical analyses of formal rating scales during acute therapy in a controlled clinical trial comparing oral olanzapine at 3 fixed doses with placebo in the treatment of schizophrenia in a 6-week trial.

It is important that you continue to give olanzapine during this time. In placebo-controlled clinical trials 6-12 weeks duration of elderly patients mean age 78 years with dementia-related psychosis and or disturbed behaviours, there was a 2-fold increase in the incidence of death in olanzapine-treated patients compared to patients treated with placebo 3.

Plasma concentrations, half-life, and clearance of olanzapine may vary between individuals on the basis of smoking status, gender, and age. People with cancer may commonly experience distressing nausea and vomiting, despite the current medications available, before, during, and after chemotherapy or radiotherapy, and during a palliative phase of illness when the aim of treatment is symptom relief rather than cure.

Undesirable alterations in lipids have been observed in olanzapine-treated patients in placebocontrolled clinical trials see section 4.

Side Effects

  • Uncaring feelings
  • Lack of appetite
  • Loss of interest or pleasure
  • Muscle tension or tightness
  • Excessive Thirst

Used for

  • Schizoaffective Disorder
  • Bipolar Disorder

Before using

Ask your doctor before use if you are taking the following medications:

Pregnancy

  • Since this drug is absorbed through the skin and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication.
  • You may need to take a pregnancy test.
  • Women of childbearing years should take a pregnancy test before starting this medication.

Common dosage / Overdose

  • Changes in thyroid status of the patient may necessitate adjustment in dosage.
  • PO 3 or 4 times a day.
  • If you have an infection that is harder to treat, such as a foot or nail infection, your doctor may tell you to take 750 mg per day in divided doses.
  • Do not take 2 doses together to make up for a missed dose.
  • PO given in divided doses for up to 2 years.
  • They will slowly increase the dose until the recommended amount is reached.

Warnings

It is important to seek medical advice from your doctor if you get pregnant or plan to have a baby while taking this medicine, so that you can discuss the potential risks to the baby if you keep taking the medicine, compared with other treatments or the risks of stopping treatment.

While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile.

TCA concentrations may need to be monitored, and the dose of TCA may need to be reduced.

Increased aggression has been identified in some male patients and the FDA in the USA has advised clinicians to warn potential patients about this side effect.

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Olanzapine may worsen any bowel obstruction or blockages. Abnormal dreams, abnormal thinking, auditory hallucinations, decreased libido, restlessness, sleep disorder. Your doctor should check your blood sugar levels before and during treatment with this drug. Cerebrovascular effects including, stroke and transient ischemic attack resulting in death reported. In the tables and tabulations that follow, MedDRA and COSTART Dictionary terminology has been used to classify reported adverse reactions.

Resources

  • http://www.news-medical.net/health/What-is-Olanzapine.aspx
  • http://www.rxlist.com/consumer_olanzapine/drugs-condition.htm
  • http://medlineplus.gov/druginfo/meds/a601213.html

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