No detailed information is available on the metabolic fate of procyclidine but very little of the parent compound is excreted in the urine unchanged.
The usual maintenance dose to achieve optimal response is 15 mg to 30 mg procyclidine per day.
Acetaminophen The risk or severity of adverse effects can be increased when Procyclidine is combined with Acetaminophen.
The effective maintenance dose is usually 10 mg to 30 mg procyclidine per day. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Procyclidine is also used to control troublesome extrapyramidal symptoms induced by neuroleptic drugs including pseudo-parkinsonism, acute dystonic reactions and akathisia. This medication decreases saliva production, an effect that can increase gum and tooth problems e.
Procyclidine may potentiate the vagolytic effects of quinidine. Elderly patients, especially those on high doses of anticholinergics may be more susceptible to the adverse events associated with such therapy See ADVERSE EVENTS.
Ask your doctor before use if you are taking the following medications:
The lowest effective dosage should be used.
Adverse events were monitored throughout the study.
Pheochromocytoma crisis, which can be fatal, has been reported after administration of systemic corticosteroids.
Contraindicated in patients with concurrent treatment with MAOIs, recent heart attack, heart diseases, severe liver disease and hypersensitivity.
This can cause these muscles to tighten, which narrows the airways in your lungs.
Do not breast feed while taking this drug without consulting physician. Although the cases of abuse are rare, physicians should exercise caution in prescribing procyclidine to patients with symptoms that may not be genuine. Procyclidine hydrochloride was developed at The Wellcome Research Laboratories as the most promising of a series of antiparkinsonism compounds produced by chemical modification of antihistamines.
Cessation of treatment periodically is to be recommended even in patients who appear to require the drug for longer periods.