Norfloxacin prophylaxis is cost effective in reducing recurrent SBP.
Norfloxacin is used to treat urinary tract and gastrointestinal infections.
Exactly norfloxacin inhibits the DNA gyrase enzyme present in the bacteria which leads to hindrance in the normal supercoil formation of the DNA.
Intravenous ceftriaxone has been shown to be more effective than oral norfloxacin for SBP prophylaxis in patients with advanced cirrhosis and gastrointestinal hemorrhage. Older adults may be at greater risk for tendon problems and QT prolongation see above while using this drug.
Norfloxacin AN tablets do not contain gluten, lactose, sucrose, tartrazine or any other azo dyes. If you develop severe diarrhoea, tell your doctor or pharmacist immediately. When a 200-mg dose of NOROXIN was administered to nursing mothers, norfloxacin was not detected in human milk. Patients taking any of these drugs concomitantly with norfloxacin should be carefully monitored.
Animal studies show risk and human studies not available or neither animal nor human studies done. Clostridium Difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including NOROXIN and may range in severity from mild diarrhea to fatal colitis.
Ask your doctor before use if you are taking the following medications:
The incidence of this disorder increases in cases of hypoalbuminaemia and previous renal insufficiency.
Anyone considering the use of this medicine or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need.
Older adults may be at greater risk for side effects such as low blood sugar or lactic acidosis.
After use, patients should be monitored for signs and symptoms of bronchospasm or other respiratory distress, including physical exam with chest auscultation, at least every 15 minutes for a minimum of one hour.
Coadministration of pentazocine with skeletal muscle relaxants may result in additive respiratory and CNS depression and anticholinergic effects, such as urinary retention and constipation.
If you have myasthenia gravis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. May cause false positive on opiate screening tests. Drug information contained herein may be time sensitive. These interpretative criteria apply only to isolates from urinary tract infections. These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds.