Because high and prolonged serum antibiotic concentrations can occur, the total daily dose of cefpodoxime proxetil should be reduced in these patients.
If you stop taking cefpodoxime too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
Mutagenesis studies of cefpodoxime, including the Ames test both with and without metabolic activation, the chromosome aberration test, the unscheduled DNA synthesis assay, mitotic recombination and gene conversion, the forward gene mutation assay and the in vivo micronucleus test, were all negative.
Cefpodoxime is a prescription drug used to treat a wide variety of bacterial infections. In the present study, independently of the prescribed regimen, a statistically significant difference in failure rates with the 3-day therapeutic course was observed only in patients with a previous history of three or more episodes of acute cystitis per year. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. All isolates were identified with an API system bioMerieux, Marcy l Etoile, France , and antimicrobial susceptibility testing was performed as described by the National Committee for Clinical Laboratory Standards 15.
Continue to take cefpodoxime until you finish the prescription even if you feel better. Unless your doctor tells you otherwise, continue your normal diet. Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. How should this medicine be used.
Refer to the prescribing information for complete details.
Ask your doctor before use if you are taking the following medications:
Use of pimozide and medications known to cause electrolyte imbalance may increase the risk of QT prolongation.
Be sure to brush your teeth carefully and see a dentist regularly during your treatment to decrease the risk that you will develop this side effect.
Dose adjustments should be made based on the total weekly dosage, with increases or decreases of 10 to 20 percent spread out over the week.
Sorry, We Cannot Find the Page You Requested. There have been no recent studies on the treatment of disseminated gonococcal infection. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported.
It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora.
These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. Drugs that have quantity limits associated with each prescription.