Isoniazid inhibits the metabolism of CYP3A4, and therefore may inhibit the hepatic metabolism of certain corticosteroids including budesonide.
Talk to your doctor if you are breastfeeding or plan to breastfeed before or while taking budesonide.
However, budesonide has limited systemic availability and there remains little scientific data in this regard. Prednisone is a corticosteroid and budesonide is a glucocorticoid. Estrogens may reduce the action of enzymes in the liver that break down eliminate the active form of prednisone, prednisolone. Summers RW, Switz DM, Sessions JT Jr, et al. These synthetic corticosteroids mimic the action of cortisol hydrocortisone , a naturally-occurring hormone produced in the body.
Ask your doctor before use if you are taking the following medications:
The risk was more evident for cardiovascular death, in patients with severe COPD, and at a higher daily dose.
Do not use unless need is life saving.
Elevated lactic acid concentrations are associated with increased morbidity rates. When corticosteroids are administered exogenously, increases in blood glucose concentrations would be expected thereby decreasing the hypoglycemic effect of antidiabetic agents. Talk to your doctor about other drug options that may work for you. Serum potassium levels should be monitored in patients receiving these drugs concomitantly.
Patients receiving antidiabetic agents should be closely monitored for signs indicating loss of diabetic control when corticosteroids are instituted.